Bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecules for redirected T-cell cytotoxicity in hematological malignancies

被引:2
|
作者
Comeau, Michael R.
Mitchell, Danielle
Gottschalk, Rebecca
Misher, Lynda
Daugherty, Mollie
Parr, Lara
Pavlik, Peter
Woodruff, Brian
Fang, Hang
Aguilar, Megan
Bannink, Jeannette
Johnson, Starrla
Li, Gary
Miller, Robert E.
Bader, Robert
Zhang, Nicole
Sewell, Toddy
Dasovich, Maria
Hoyos, Gabriela H.
Blankenship, John W.
McMahan, Catherine
Bienvenue, David
Gross, Jane A.
机构
关键词
D O I
10.1158/1538-7445.AM2017-597
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
597
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Characterization of APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, in preclinical models of AML and nonhuman primates
    Comeau, Michael R.
    Miller, Robert E.
    Bannink, Jeannette
    Johnson, Starrla
    Bader, Robert
    Gottschalk, Rebecca
    Misher, Lynda
    Mitchell, Danielle
    Parr, Lara
    DeFrancesco, Melissa
    Bienvenue, David
    McMahan, Catherine J.
    Hoyos, Gabriela H.
    Gross, Jane A.
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [2] APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR® molecule for redirected T-cell cytotoxicity, induces potent T-cell activation, proliferation and cytotoxicity with limited cytokine release
    Comeau, Michael R.
    Miller, Robert E.
    Bader, Robert
    Gottschalk, Rebecca
    Daugherty, Mollie
    Sewell, Toddy
    Misher, Lynda
    Parr, Lara
    DeFrancesco, Melissa
    Bienvenue, David
    McMahan, Catherine J.
    Hoyos, Gabriela H.
    Gross, Jane A.
    CANCER RESEARCH, 2018, 78 (13)
  • [3] APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity with limited cytokine release, is well tolerated in repeat dose toxicology studies in cynomolgus macaques
    Comeau, Michael R.
    Gottschalk, Rebecca
    Daugherty, Mollie
    Sewell, Toddy
    Misher, Lynda
    Jeannette, Bannink
    Johnson, Starrla
    Parr, Lara
    Kumer, John
    Jablonski, David
    DeFrancesco, Melissa
    Bienvenue, David
    Hoyos, Gabriela H.
    McMahan, Catherine J.
    Gross, Jane A.
    CANCER RESEARCH, 2019, 79 (13)
  • [4] Bispecific Anti-CD123 x Anti-CD3 Adaptir™ Molecules APVO436 and APVO437 Have Broad Activity Against Primary Human AML Cells In Vitro
    Godwin, Colin D.
    Bates, Olivia M.
    Laszlo, George S.
    Gottschalk, Rebecca
    Comeau, Michael R.
    Hoyos, Gabriela H.
    Walter, Roland B.
    BLOOD, 2017, 130
  • [5] Bispecific anti-CD3×anti-CD155 antibody mediates T-cell immunotherapy in human haematologic malignancies
    Li Ma
    Juan Ma
    Xin Sun
    Honggang Liu
    Investigational New Drugs, 2023, 41 : 522 - 531
  • [6] Updated Results from a Phase 1 Study of APVO436, a Novel Bispecific Anti-CD123 x Anti-CD3 Adaptir T Molecule, in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome
    Watts, Justin
    Maris, Michael
    Lin, Tara L.
    Patel, Prapti
    Madanat, Yazan F.
    Cogle, Christopher R.
    Borthakur, Gautam
    Huebner, Dirk
    Khaskhely, Noor
    Bonham, Lynn
    Massaro, Monica
    Taylor, Daphne
    Taromino, Caroline
    Mims, Alice S.
    BLOOD, 2022, 140 : 6204 - 6205
  • [7] THE ROLE OF T-CELL ACTIVATION IN ANTI-CD3 X ANTITUMOR BISPECIFIC ANTIBODY THERAPY
    WEINER, GJ
    KOSTELNY, SA
    HILLSTROM, JR
    COLE, MS
    LINK, BK
    WANG, SL
    TSO, JY
    JOURNAL OF IMMUNOLOGY, 1994, 152 (05): : 2385 - 2392
  • [8] A Novel Combination of Anti-CD3 x Anti-CD123 Monoclonal Antibodies to Redirect Activated T Cells to Target Acute Myelogenous Leukemia
    Kubicka, Ewa
    Lum, Lawrence G.
    Thakur, Archana
    BLOOD, 2017, 130
  • [9] Anti-CD123 CAR T-Cell Therapy for the Treatment of Myelodysplastic Syndrome
    Zhang, Wei
    Stevens, Brett M.
    Budde, Elizabeth
    Forman, Stephen J.
    Schulte, Brian C.
    Jordan, Craig T.
    Purev, Enkhtsetseg
    MOLECULAR THERAPY, 2017, 25 (05) : 268 - 268
  • [10] Anti-CD123 CAR T-Cell Therapy for the Treatment of Myelodysplastic Syndrome
    Zhang, Wei
    Stevens, Brett M.
    Budde, Elizabeth Elizabeth
    Forman, Stephen J.
    Jordan, Craig T.
    Purev, Enkhtsetseg
    BLOOD, 2017, 130