Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges

被引：38

作者：

Maeda, Tadao ^{[1
,2
,3
]}

Mandai, Michiko ^{[1
,2
,3
]}

Sugita, Sunao ^{[1
,2
,3
,4
]}

Kime, Cody ^{[3
,5
]}

Takahashi, Masayo ^{[1
,2
,3
,4
]}

机构：

[1] Kobe City Eye Hosp, Res Ctr, Kobe, Hyogo 6500047, Japan

[2] Kobe City Eye Hosp, Dept Ophthalmol, Kobe, Hyogo 6500047, Japan

[3] RIKEN Ctr Biosyst Dynam Res, Lab Retinal Regenerat, Kobe, Hyogo 6500047, Japan

[4] Vis Care Inc, Kobe, Hyogo 6500047, Japan

[5] Trans Ova Genet, Sioux Ctr, IA USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 05期

关键词：

PIGMENT EPITHELIAL-CELLS; IMMUNE PRIVILEGE; IPS CELLS; TRANSCRIPTION FACTORS; MOUSE FIBROBLASTS; DIRECT CONVERSION; VISUAL FUNCTION; NEURAL RETINA; TRANSPLANTATION; SHEETS;

D O I：

10.1016/j.molmed.2022.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) transplantation, the safety of the technique has started to clarify, and clinical study on further advances such as the long desired transplantation of iPSC-derived retina to treat retinitis pigmentosa (RP) has begun. Ophthalmologists are now working closely with basic researchers to incorporate new technology areas with a synergy that is anticipated to realize the practical application of stem cell-based therapy for retinal degeneration.

引用

页码：388 / 404

页数：17

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