Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges

被引：38
作者：
Maeda, Tadao [1 ,2 ,3 ]
Mandai, Michiko [1 ,2 ,3 ]
Sugita, Sunao [1 ,2 ,3 ,4 ]
Kime, Cody [3 ,5 ]
Takahashi, Masayo [1 ,2 ,3 ,4 ]
机构：
[1] Kobe City Eye Hosp, Res Ctr, Kobe, Hyogo 6500047, Japan
[2] Kobe City Eye Hosp, Dept Ophthalmol, Kobe, Hyogo 6500047, Japan
[3] RIKEN Ctr Biosyst Dynam Res, Lab Retinal Regenerat, Kobe, Hyogo 6500047, Japan
[4] Vis Care Inc, Kobe, Hyogo 6500047, Japan
[5] Trans Ova Genet, Sioux Ctr, IA USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 05期
关键词：
PIGMENT EPITHELIAL-CELLS; IMMUNE PRIVILEGE; IPS CELLS; TRANSCRIPTION FACTORS; MOUSE FIBROBLASTS; DIRECT CONVERSION; VISUAL FUNCTION; NEURAL RETINA; TRANSPLANTATION; SHEETS;
D O I：
10.1016/j.molmed.2022.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) transplantation, the safety of the technique has started to clarify, and clinical study on further advances such as the long desired transplantation of iPSC-derived retina to treat retinitis pigmentosa (RP) has begun. Ophthalmologists are now working closely with basic researchers to incorporate new technology areas with a synergy that is anticipated to realize the practical application of stem cell-based therapy for retinal degeneration.
引用
收藏
页码：388 / 404
页数：17
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