Liver transplantation for neuroendocrine tumour liver metastases

被引：69

作者：

Fan, Sheung Tat ^{[1
,2
]}

Le Treut, Yves Patrice ^{[3
]}

Mazzaferro, Vincenzo ^{[4
]}

Burroughs, Andrew K. ^{[5
]}

Olausson, Michael ^{[7
]}

Breitenstein, Stefan ^{[8
]}

Frilling, Andrea ^{[6
]}

机构：

[1] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Sanat & Hosp, Liver Surg Ctr, Hong Kong, Hong Kong, Peoples R China

[3] Hop Conception, Serv Chirurg Gen & Transplantat Hepat, Marseille, France

[4] Ist Nazl Tumori, Gastrointestinal & Hepatopancreat Surg & Liver Tr, I-20133 Milan, Italy

[5] UCL, Sch Med, London W1N 8AA, England

[6] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London, England

[7] Sahlgrenska Transplant Inst, Gothenburg, Sweden

[8] Univ Zurich Hosp, Dept Visceral & Transplant Surg, Swiss Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland

来源：

HPB | 2015年 / 17卷 / 01期

关键词：

SINGLE-CENTER EXPERIENCE; ENDOCRINE TUMORS; EUROPE;

D O I：

10.1111/hpb.12308

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

ObjectiveSearch and review of available literature were made to define the indications for and timing of liver transplantation for neuroendocrine tumour (NET) liver metastases. MethodsElectronic bibliographical databases were searched. Prospective and retrospective cohort studies and case-controlled studies were used for qualitative and quantitative synthesis of the systematic review. Reports of patients with liver transplantation alone for NET liver metastases of any origin or combined with resection of extrahepatic tumour deposits were recruited. ResultsThe number of patients who have undergone liver transplantation for NET liver metastases is 706. The post-transplant 5-year survival rate from the time of diagnosis was approximately 70%. NET patients with metastases confined to the liver and not poorly differentiated are favourable candidates for liver transplantation. Selection of patients based on evolution of tumours over 6 months is not recommended. ConclusionNon-resectable NET liver metastasis resistant to medical treatment and confined to the liver is an accepted indication for liver transplantation.

引用

页码：23 / 28

页数：6

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