Deprotonation of the Asp1-Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH

被引：107

作者：

Hureau, Christelle ^{[1
,2
,3
]}

Coppel, Yannick ^{[1
,2
,3
]}

Dorlet, Pierre ^{[4
,5
]}

Solari, Pier Lorenzo ^{[6
]}

Sayen, Stephanie ^{[7
]}

Guillon, Emmanuel ^{[7
]}

Sabater, Laurent ^{[1
,2
,3
]}

Faller, Peter ^{[1
,2
,3
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse, France

[2] Univ Toulouse, F-31077 Toulouse, France

[3] UPS, INPT, F-31077 Toulouse, France

[4] CNRS, Lab Stress Oxydant & Detoxicat, F-91191 Gif Sur Yvette, France

[5] CEA, IBiTec S, SB2SM, F-91191 Gif Sur Yvette, France

[6] Synchrotron SOLEIL, F-91192 Gif Sur Yvette, France

[7] Inst Chim Mol Reims, Reims, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 50期

关键词：

amyloid beta-peptides; binding sites; copper; deprotonation; NMR spectroscopy; ZINC-BINDING SITE; ALZHEIMERS-DISEASE; COORDINATION; PRION; NMR; ION; AFFINITY; FEATURES; LIGAND; CU2+;

D O I：

10.1002/anie.200904512

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：9522 / 9525

页数：4

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