Terrenolide S, a new antileishmanial butenolide from the endophytic fungus Aspergillus terreus

被引：59

作者：

Elkhayat, Ehab S. ^{[1
]}

Ibrahim, Sabrin R. M. ^{[2
,3
]}

Mohamed, Gamal A. ^{[1
,4
]}

Ross, Samir A. ^{[5
]}

机构：

[1] Al Azhar Univ, Dept Pharmacognosy, Fac Pharm, Assiut Branch, Assiut, Egypt

[2] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawwarah, Saudi Arabia

[3] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt

[4] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21413, Saudi Arabia

[5] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 07期

关键词：

Aspergillus terreus; terrenolide S; butenolide; stigmasterol derivatives; antimicrobial; antileishmanial; antimalarial; cytotoxic activity; BUTYROLACTONE; TERRETONIN; METABOLITE;

D O I：

10.1080/14786419.2015.1072711

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Terrenolide S, a new butenolide derivative (6), together with six known compounds: (22E,24R)-stigmasta-5,7,22-trien-3--ol (1), stigmast-4-ene-3-one (2), stigmasta-4,6,8(14),22-tetraen-3-one (3), terretonin A (4), terretonin (5) and butyrolactone VI (7) have been isolated from the endophytic fungus Aspergillus terreus isolated from the roots of Carthamus lanatus (Asteraceae). Their structures were established by extensive spectroscopic analyses (1D, 2D NMR and HRESIMS), as well as optical rotation measurement and comparison with literature data. Compound 1 displayed a potent activity towards methicillin-resistant Staphylococcus aureus (MRSA) and Cryptococcus neoformans with IC50 values of 2.29 and 10.68 mu M, respectively. Moreover, 1, 2 and 6 exhibited antileishmanial activity towards Leishmania donovani with IC50 values of 11.24, 15.32 and 27.27 mu M, respectively and IC90 values of 14.68, 40.56 and 167.03 mu M, respectively.

引用

页码：814 / 820

页数：7

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