Copper-Mediated N-Heteroarylation of Primary Sulfonamides: Synthesis of Mono-N-heteroaryl Sulfonamides

被引：85
作者：
Baffoe, Jonathan [1 ]
Hoe, Madelene Y. [1 ]
Toure, B. Barry [1 ]
机构：
[1] Novartis Inst Biomed Res Inc, Oncol, Global Discovery Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 07期
关键词：
CROSS-COUPLING REACTION; ARYL HALIDES; C-N; GOLDBERG REACTIONS; BOND FORMATION; ULLMANN; ACID; ARYLATION; AMIDATION; PALLADIUM;
D O I：
10.1021/ol100263r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides. The electronic factors that influence the course of the reaction have also been Investigated.
引用
收藏
页码：1532 / 1535
页数：4
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