Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network

被引：74

作者：

Whitesell, Jennifer D. ^{[1
]}

Liska, Adam ^{[2
,3
]}

Coletta, Ludovico ^{[2
,4
]}

Hirokawa, Karla E. ^{[1
]}

Bohn, Phillip ^{[1
]}

Williford, Ali ^{[1
]}

Groblewski, Peter A. ^{[1
]}

Graddis, Nile ^{[1
]}

Kuan, Leonard ^{[1
]}

Knox, Joseph E. ^{[1
]}

Ho, Anh ^{[1
]}

Wakeman, Wayne ^{[1
]}

Nicovich, Philip R. ^{[1
]}

Nguyen, Thuc Nghi ^{[1
]}

van Velthoven, Cindy T. J. ^{[1
]}

Garren, Emma ^{[1
]}

Fong, Olivia ^{[1
]}

Naeemi, Maitham ^{[1
]}

Henry, Alex M. ^{[1
]}

Dee, Nick ^{[1
]}

Smith, Kimberly A. ^{[1
]}

Levi, Boaz ^{[1
]}

Feng, David ^{[1
]}

Ng, Lydia ^{[1
]}

Tasic, Bosiljka ^{[1
]}

Zeng, Hongkui ^{[1
]}

Mihalas, Stefan ^{[1
]}

Gozzi, Alessandro ^{[2
]}

Harris, Julie A. ^{[1
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98109 USA

[2] Ist Italiano Tecnol, Funct Neuroimaging Lab, Ctr Neurosci & Cognit Syst UniTn, I-38068 Rovereto, Italy

[3] DeepMind, London EC4A 3TW, England

[4] Univ Trento, Ctr Mind Brain Sci CIMeC, I-38068 Rovereto, Italy

来源：

NEURON | 2021年 / 109卷 / 03期

基金：

欧洲研究理事会;

关键词：

SCALE FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; ORGANIZATION; ARCHITECTURE; DRIVER; LINES;

D O I：

10.1016/j.neuron.2020.11.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain disorders. How disease affects the DMN is unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity to investigate structural connectivity of the DMN across spatial scales with cell-type resolution. We co-registered maps from functional magnetic resonance imaging and axonal tracing experiments into the 3D Allen mouse brain reference atlas. We find that the mouse DMN consists of preferentially interconnected cortical regions. As a population, DMN layer 2/3 (L2/3) neurons project almost exclusively to other DMN regions, whereas L5 neurons project in and out of the DMN. In the retrosplenial cortex, a core DMN region, we identify two L5 projection types differentiated by in-or out-DMN targets, laminar position, and gene expression. These results provide a multi-scale description of the anatomical correlates of the mouse DMN.

引用

收藏

页码：545 / 559.e8

页数：24

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