20D-dynamic representation of protein sequences

被引：29

作者：

Czerniecka, Agata ^{[1
]}

Bielinska-Waz, Dorota ^{[1
]}

Waz, Piotr ^{[2
]}

Clark, Tim ^{[3
,4
]}

机构：

[1] Med Univ Gdansk, Dept Radiol Informat & Stat, Tuwima 15, PL-80210 Gdansk, Poland

[2] Med Univ Gdansk, Dept Nucl Med, Tuwima 15, PL-80210 Gdansk, Poland

[3] Univ Erlangen Nurnberg, Comp Chem Ctr, Nagelsbachstr 25, D-91052 Erlangen, Germany

[4] Univ Erlangen Nurnberg, Interdisciplinary Ctr Mol Mat, Nagelsbachstr 25, D-91052 Erlangen, Germany

来源：

GENOMICS | 2016年 / 107卷 / 01期

关键词：

Similarity/dissimilarity analysis of protein sequences; Descriptors; Alignment-free methods; Moments of inertia; 2-D GRAPHICAL REPRESENTATION; PHYSICOCHEMICAL PROPERTIES; SIMILARITY ANALYSIS; SIMILARITY/DISSIMILARITY ANALYSIS; 3D-DYNAMIC REPRESENTATION; DISTRIBUTION MOMENTS; QSAR MODEL; DESCRIPTORS; PREDICTION; BIOMARKERS;

D O I：

10.1016/j.ygeno.2015.12.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new method of comparison of protein sequences has been formulated. The sequence of amino acids is represented by a set of point masses in a 20D space. The distribution of points in the space is obtained by applying the method of a walk in the 20D space. Projections of the 20D representation into 2D or 3D spaces illustrate the distribution of particular amino acids along the sequence. 20D moments of inertia are proposed as new descriptors of protein sequences. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：16 / 23

页数：8

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