3-Chloro-6-{4-[3-(trifluoromethyl)-phenyl]piperazin-1-yl}pyridazine

被引：0

作者：

Arslan, Hakan ^{[1
,2
]}

Utku, Semra ^{[3
]}

Hardcastle, Kenneth I. ^{[1
]}

Gokce, Mehtap ^{[4
]}

Lense, Sheri ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[2] Mersin Univ, Fac Arts & Sci, Dept Chem, TR-33343 Mersin, Turkey

[3] Mersin Univ, Fac Pharm, Dept Pharmaceut Sci, TR-33169 Mersin, Turkey

[4] Gazi Univ, Fac Pharm, Dept Pharmaceut Sci, TR-06330 Ankara, Turkey

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷

关键词：

ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; AGENTS;

D O I：

10.1107/S1600536810004137

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, C15H14ClF3N4, was synthesized from 3,6-dichloropyridazine and 1-[3-(trifluoromethyl) phenyl] piperazine. The piperazine ring is flanked by 3-chloropyridazine and 3-trifluoromethylphenyl rings and adopts a chair conformation, whereas the 3-chloropyridazine and 3-trifluoromethylphenyl rings are planar, with maximum deviations of 0.0069 (13) and 0.0133 (14) angstrom respectively. The crystal structure is stabilized by weak intermolecular C-H center dot center dot center dot N hydrogen-bond interactions.

引用

页码：O532 / U4263

页数：11

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