Adipose tissue lymphocytes: types and roles

被引:37
作者
Caspar-Bauguil, S. [1 ,2 ,3 ]
Cousin, B. [1 ,2 ]
Bour, S. [1 ]
Castiella, L. [1 ,2 ]
Penicaud, L. [1 ,2 ,4 ]
Carpene, C. [5 ,6 ]
机构
[1] Univ Toulouse 3, UPS, UMR Metab Plast & Mitochondrie 5241, F-31062 Toulouse, France
[2] CNRS, UMR 5241, Toulouse, France
[3] CHU Rangueil, Serv Biochim, F-31054 Toulouse, France
[4] Univ Bourgogne, CNRS, UMR5548, Dijon, France
[5] Univ Toulouse 3, UPS, Inst Med Mol Rangueil, IFR 150, F-31062 Toulouse, France
[6] Fac Med Toulouse, INSERM, U858, F-31073 Toulouse, France
关键词
Leukocytes; Stroma-vascular fraction; Adipocytes; Adipokines; Obesity; Diabetes; INSULIN-RESISTANCE; IMMUNE-RESPONSE; ADHESION RECEPTORS; HUMAN ADIPOCYTES; CELL-FUNCTION; OB/OB MICE; T-CELLS; OBESITY; LEPTIN; INFLAMMATION;
D O I
10.1007/BF03185938
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
S. CASPAR-BAUGUIL, B. COUSIN, S. BOUR, L. CASTIELLA, L. PENICAUD and C. CARPENE. Adipose tissue lymphocytes: types and roles (minireview). J Physiol Biochem, 65 (4), 423-436, 2009. Besides adipocytes, specialized in lipid handling and involved in energy balance regulation, white adipose tissue (WAT) is mainly composed of other cell types among which lymphocytes represent a non-negligible proportion. Different types of lymphocytes (B, alpha beta T, gamma delta K and NKT) have been detected in WAT of rodents or humans, and vary in their relative proportion according to the fat pad anatomical location. The lymphocytes found in intra-abdominal, visceral fat pads seem representative of innate immunity, while those present in subcutaneous fat depots are part of adaptive immunity, at least in mice. Both the number and the activity of the different lymphocyte classes, except B lymphocytes, are modified in obesity. Several of these modifications in the relative proportions of the lymphocyte classes depend on the degree of obesity, or on leptin concentration, or even fat depot anatomical location. Recent studies suggest that alterations of lymphocyte number and composition precede the macrophage increase and the enhanced inflammatory state of WAT found in obesity. Lymphocytes express receptors to adipokines while several pro-inflammatory chemokines are produced in WAT, rendering intricate crosstalk between fat and immune cells. However, the evidences and controversies available so far are in favour of an involvement of lymphocytes in the control of the number of other cells in WAT, either adipocytes or immune cells and of their secretory and metabolic activities. Therefore, immunotherapy deserves to be considered as a promising approach to treat the endocrino-metabolic disorders associated to excessive fat mass development.
引用
收藏
页码:423 / 436
页数:14
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