Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica

被引：24

作者：

Qi, Bowen ^{[1
]}

Yang, Wanqing ^{[1
]}

Ding, Ning ^{[1
]}

Luo, Yuan ^{[1
]}

Jia, Fangfang ^{[1
]}

Liu, Xiao ^{[1
]}

Wang, Juan ^{[1
]}

Wang, Xiaohui ^{[1
]}

Tu, Pengfei ^{[1
]}

Shi, Shepo ^{[1
,2
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Beijing Key Lab Qual Evaluat Chinese Meteria Med, Beijing 100029, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2019年 / 73卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Angelica dahurica; Pyrrole 2-carbaldehyde alkaloid; Dahurines A-F; AChE inhibitory activity; PENICILLIUM-CHRYSOGENUM MT-12; ENDOPHYTIC FUNGUS; DIMERIC FURANOCOUMARINS; IDENTIFICATION; DERIVATIVES; COUMARINS;

D O I：

10.1007/s11418-019-01328-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new pyrrole 2-carbaldehyde derived alkaloids, dahurines A-F (1-6), along with five known ones (7-11) and butyl 2-pyrrolidone-5-carboxylate (12) were isolated from the roots of Angelica dahurica. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Although compounds 7 and 8 have been chemically synthesized, they were obtained from natural materials for the first time. Compounds 2, 3, 4, 10, and 11 exhibited acetylcholinesterase inhibitory activity with IC50 values in the range of 47.5-52.5 mu M. [GRAPHICS] .

引用

页码：769 / 776

页数：8

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