Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression

被引：4

作者：

Xu, Feixue ^{[1
]}

Si, Xiaoqiang ^{[2
]}

Du, Jingran ^{[1
]}

Xu, Feihua ^{[3
]}

Yang, Aihong ^{[1
]}

Zhang, Caixia ^{[1
]}

Zhang, Xiucai ^{[1
]}

Yang, Yongxiu ^{[1
]}

机构：

[1] Lanzhou Univ, First Hosp, Dept Gynecol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Gansu Prov Hosp, Dept Plast Surg, Lanzhou 730000, Gansu, Peoples R China

[3] Lanzhou Univ, Dept Labor & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

来源：

ONCOLOGY LETTERS | 2019年 / 18卷 / 03期

关键词：

synaptic cell adhesion molecules; ovarian cancer; membrane palmitoylated protein 6 MPP6; biomarker; molecular targets; ADHESION MOLECULE; TUMOR-SUPPRESSOR; UP-REGULATION; TSLC1; RESISTANCE; NECTIN; GROWTH; GENES; IGSF4; SAA3;

D O I：

10.3892/ol.2019.10542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Synaptic cell adhesion molecules (SynCAMs) are single transmembrane proteins that belong to the immunoglobulin superfamily of cell adhesion molecules. In the present study, a decrease in SynCAM levels in ovarian tumor tissues compared with normal tissues is reported; the downregulation was accompanied by the grade malignancy. The observations suggested that SynCAM may be essential for important novel functions in ovarian cancer. Further experiments showed that low SynCAM expression inhibited membrane palmitoylated protein 6 (MPP6) expression, a member of the palmitoylated membrane protein subfamily of peripheral membrane-associated guanylate kinases. In addition, low levels of MPP6 in ovarian tumor tissues correlated with shorter patient survival. A SynCAM-regulated pathway may provide molecular targets for the treatment of ovarian cancer and novel biomarkers to be used in clinical diagnosis.

引用

页码：2477 / 2483

页数：7

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