Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

被引：354

作者：

Supasa, Piyada ^{[1
]}

Zhou, Daming ^{[2
]}

Dejnirattisai, Wanwisa ^{[1
]}

Liu, Chang ^{[1
,3
]}

Mentzer, Alexander J. ^{[1
,4
]}

Ginn, Helen M. ^{[5
]}

Zhao, Yuguang ^{[2
]}

Duyvesteyn, Helen M. E. ^{[2
]}

Nutalai, Rungtiwa ^{[1
]}

Tuekprakhon, Aekkachai ^{[1
]}

Wang, Beibei ^{[1
]}

Paesen, Guido C. ^{[2
]}

Slon-Campos, Jose ^{[1
]}

Lopez-Camacho, Cesar ^{[1
]}

Hallis, Bassam ^{[6
]}

Coombes, Naomi ^{[6
]}

Bewley, Kevin R. ^{[6
]}

Charlton, Sue ^{[6
]}

Walter, Thomas S. ^{[2
]}

Barnes, Eleanor ^{[4
,7
,8
,9
]}

Dunachie, Susanna J. ^{[4
,7
,10
,11
]}

Skelly, Donal ^{[4
,7
,12
]}

Lumley, Sheila F. ^{[4
,8
,13
]}

Baker, Natalie ^{[6
]}

Shaik, Imam ^{[6
]}

Humphries, Holly E. ^{[6
]}

Godwin, Kerry ^{[6
]}

Gent, Nick ^{[6
]}

Sienkiewicz, Alex ^{[6
]}

Dold, Christina ^{[8
,14
]}

Levin, Robert ^{[15
]}

Dong, Tao ^{[3
,13
,16
]}

Pollard, Andrew J. ^{[8
,14
]}

Knight, Julian C. ^{[1
,4
,8
]}

Klenerman, Paul ^{[4
,7
,8
,9
]}

Crook, Derrick ^{[13
]}

Lambe, Teresa ^{[17
]}

Clutterbuck, Elizabeth ^{[8
,14
]}

Bibi, Sagida ^{[8
,14
]}

Flaxman, Amy ^{[17
]}

Bittaye, Mustapha ^{[17
]}

Belij-Rammerstorfer, Sandra ^{[17
]}

Gilbert, Sarah ^{[17
]}

Hall, David R. ^{[5
]}

Williams, Mark A. ^{[5
]}

Paterson, Neil G. ^{[5
]}

James, William ^{[18
]}

Carroll, Miles W. ^{[1
,6
]}

Fry, Elizabeth E. ^{[2
]}

Mongkolsapaya, Juthathip ^{[1
,3
,19
]}

机构：

[1] Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England

[2] Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Div Struct Biol, Oxford, England

[3] Univ Oxford, Chinese Acad Med Sci CAMS, Oxford Inst COI, Oxford, England

[4] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[5] Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot, Oxon, England

[6] Publ Hlth England PHE, Natl Infect Serv, Salisbury, Wilts, England

[7] Peter Medawar Bldg Pathogen Res, Oxford, England

[8] NIHR Oxford Biomed Res Ctr, Oxford, England

[9] Univ Oxford, Translat Gastroenterol Unit, Oxford, England

[10] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[11] Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[12] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[13] Univ Oxford, Nuffield Dept Med, Oxford, England

[14] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[15] Worthing Dist Hosp, Worthing, England

[16] Univ Oxford, MRC Weatherall Inst Mol Med, Radcliffe Dept Med, MRC Human Immunol Unit, Oxford, England

[17] Univ Oxford, Jenner Inst, Nuffield Dept Med, Oxford, England

[18] Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England

[19] Mahidol Univ, Siriraj Hosp, Siriraj Ctr Res Excellence Dengue & Emerging Path, Dean Off Res,Fac Med, Nakhon Pathom, Thailand

[20] Instruct ERIC, Oxford House,Pkwy Court,John Smith Dr, Oxford, England

来源：

CELL | 2021年 / 184卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金; 英国科研创新办公室;

关键词：

ACE2; RECEPTOR; EXPRESSION; SYSTEM;

D O I：

10.1016/j.cell.2021.02.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1 1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501 However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed.

引用

页码：2201 / +

页数：18

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