Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity

被引：72

作者：

Mitchell, Daniel E. ^{[1
]}

Clarkson, Guy ^{[1
]}

Fox, David J. ^{[1
]}

Vipond, Rebecca A. ^{[1
]}

Scott, Peter ^{[1
]}

Gibson, Matthew I. ^{[1
,2
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 29期

基金：

英国工程与自然科学研究理事会;

关键词：

RED-BLOOD-CELLS; POLY(VINYL ALCOHOL); FREE CRYOPRESERVATION; GROWTH; RECOGNITION; POLYMER;

D O I：

10.1021/jacs.7b05822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antifreeze proteins are produced by extremophile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just 20 mu M. Structure property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.

引用

页码：9835 / 9838

页数：4

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