Expression and functions of adenylyl cyclases in the CNS

被引：43

作者：

Devasani, Karan ^{[1
]}

Yao, Yao ^{[1
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, 12901 Bruce B Downs Blvd,MDC 8, Tampa, FL 33612 USA

来源：

FLUIDS AND BARRIERS OF THE CNS | 2022年 / 19卷 / 01期

关键词：

Adenylyl cyclases; Blood-brain barrier; CNS; G-protein coupled receptors; BLOOD-BRAIN-BARRIER; GENOME-WIDE ASSOCIATION; LEFT-VENTRICULAR FUNCTION; CYCLIC ADENOSINE-MONOPHOSPHATE; INFLAMMATORY-BOWEL-DISEASE; LONG-TERM POTENTIATION; P-GLYCOPROTEIN; GENETIC ARCHITECTURE; FAMILIAL DYSKINESIA; HEARING IMPAIRMENT;

D O I：

10.1186/s12987-022-00322-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs (ADCY1-10). Next, the expression and function of each mammalian ADCY isoform are summarized in a region/cell-specific manner. Furthermore, the effects of GPCR-ADCY signaling on blood-brain barrier (BBB) integrity are reviewed. Last, current challenges and future directions are discussed. We aim to provide a succinct review on ADCYs to foster new research in the future.

引用

页数：18

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