Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis

被引：62

作者：

Frost, ML ^{[1
]}

Fogelman, I

Blake, GM

Marsden, PK

Cook, GJR

机构：

[1] Kings Coll London, Guys Kings & St Thomas Sch Med, Osteoporosis Screening & Res Unit, London WC2R 2LS, England

[2] Kings Coll London, Guys Kings & St Thomas Sch Med, Clin PET Ctr, London WC2R 2LS, England

[3] Royal Marsden Hosp, Dept Nucl Med, London SW3 6JJ, England

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期

关键词：

osteoporosis; positron emission tomography; bone turnover markers; bone formation; osteoblasts;

D O I：

10.1359/JBMR.040818

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regional bone metabolism measured using F-18-fluoride PET was assessed in 72 postmenopausal women classified as normal, osteopenic, or osteoporotic. Lower values of regional bone formation activity at the lumbar spine were seen in osteoporotic women, whereas global markers of bone formation were significantly increased.

引用

页码：1797 / 1804

页数：8

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