The effectiveness of intrauterine insemination in couples with sterility due to male infertility with and without a woman's hormone factor

Objective: To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor, Design: Retrospective analysis. Setting: Department of Gynecology and Obstetrics at the General Public Hospital, Horn, Austria. Patient(s): Seventy-eight long-standing involuntarily childless couples, Intervention(s): After a follicular phase GnRH analog (buserelin) protocol with hMG stimulation of the woman and a Percoll gradient preparation and capacitation of the man's semen, an IUI was performed, Main Outcome Measure(s): Fecundity and baby-take-home rates, Result(s): One hundred nine inseminations were followed by 53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and 38 deliveries (34.9%; 95% CI 26.0%-44.6%), Forty-nine children were born and 47 are alive (43.1%), Conclusion(s): Intrauterine insemination combined with buserelin gonadotropin stimulation, Percoll semen preparation, and sperm capacitation is a feasible solution to the problem of sterility attributable to a male factor with and without a woman's hormone factor. (C) 1998 by American Society for Reproductive Medicine.