The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections A Mirage?

被引：37
作者：
Mallat, Ziad [1 ,2 ]
Ait-Oufella, Hafid [2 ]
Tedgui, Alain [2 ]
机构：
[1] Univ Cambridge, Div Cardiovasc Med, Dept Med, Cambridge, England
[2] INSERM, U970, Paris, France
来源：
CIRCULATION RESEARCH | 2017年 / 120卷 / 11期
基金：
欧洲研究理事会;
关键词：
aneurysm; aorta; aortic dissection; connective tissue; extracellular matrix; losartan; MARFAN-SYNDROME; MICE; PROGRESSION; BIOAVAILABILITY; CONTRIBUTES; ACTIVATION; EXPRESSION; MUTATIONS; LTBP-3; CELLS;
D O I：
10.1161/CIRCRESAHA.116.310371
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
For >10 years ago, an unexpected role for the transforming growth factor-beta cytokine pathway has been put forward in driving thoracic aortic aneurysms and dissections. Here, we reassess the evidence for a detrimental transforming growth factor-beta overdrive in thoracic aortic aneurysms and dissections. In our view, most of the available mechanistic data argue against this theory.
引用
收藏
页码：1718 / 1720
页数：3
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