MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma

被引：25
作者：
Gong, Ningji [1 ]
Gong, Mingzhi [1 ]
机构：
[1] Shandong Univ, Hosp 2, Dept Emergency, Jinan, Shandong, Peoples R China
来源：
MEDICINE | 2018年 / 97卷 / 29期
关键词：
miR-221; osteosarcoma; prognosis; STEM-LIKE CELLS; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; BREAST-CANCER; CIRCULATING MIR-221; MICRORNA EXPRESSION; HUMAN GLIOBLASTOMA; COLORECTAL-CANCER; PROLIFERATION; RESISTANCE;
D O I：
10.1097/MD.0000000000011100
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study was aimed to investigate the relationship between miR-221 expression and prognosis in patients with osteosarcoma. miR-221 expression in 69 osteosarcoma specimens and corresponding noncancer tissues were characterized by quantitative reverse transcription polymerase chain reaction. The associations of miR-221 expression with clinicopathologic factors and prognosis in patients with osteosarcoma were statistically analyzed. miR-221 expression in patients with osteosarcoma was significantly higher than in the corresponding noncancer tissues (P < .01). miR-221 overexpression was significantly associated with tumor stage, metastatic status, and response to chemotherapy pretreatment. Cox regression analysis revealed that miR-221expression, metastasis, and response to chemotherapy were independent prognostic indicators for osteosarcoma. miR-221 upregulation may predict clinical outcomes in patients with osteosarcoma.
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页数：5
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