Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms

被引:99
作者
Yuan, Qianghua [1 ]
Yuan, Yan [2 ]
Zheng, Yan [1 ]
Sheng, Rong [1 ]
Liu, Li [1 ]
Xie, Fan [1 ]
Tan, Jing [1 ]
机构
[1] Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Reprod & Women Children Hosp, Sch Med & Life Sci, Chengdu 610041, Sichuan, Peoples R China
关键词
Cerebral ischemia-reperfusion injury; Polysaccharides; Protective mechanisms;
D O I
10.1016/j.biopha.2021.111303
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cerebral ischemia-reperfusion injury can lead to a series of serious brain diseases and cause death or different degrees of disability. Polysaccharide is a kind of biological macromolecule with multiple pharmacological activities and has been proven that it may be used for the treatment of cerebral I/R injury in the future. By sorting out all relevant research from 2000 to 2020, we selected 74 references and identified 22 kinds of polysaccharides. Almost all of these polysaccharides are extracted from traditional Chinese medicine. Research shows that these polysaccharides can improve cerebral ischemia-reperfusion injury through anti-oxidative stress, inhibiting the neuroinflammation, glutamate neurotoxicity and neuronal apoptosis, and exerting neurotrophic effect. The specific mechanisms include clearing ROS and RNS, inhibiting the expression of inflammatory factors, maintaining mitochondrial homeostasis and blocking caspase cascade, regulating NMDA receptor and promoting angiogenesis. We hoped this review is instructive for researchers to design, research and develop polysaccharides.
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页数:8
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  • [1] Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils
    Ahn, Ji Hyeon
    Shin, Myoung Cheol
    Kim, Dae Won
    Kim, Hyunjung
    Song, Minah
    Lee, Tae-Kyeong
    Lee, Jae-Chul
    Kim, Hyeyoung
    Cho, Jun Hwi
    Kim, Young-Myeong
    Kim, Jong-Dai
    Choi, Soo Young
    Won, Moo-Ho
    Park, Joon Ha
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (03):
  • [2] Extraction and chemical characterization of Angelica sinensis polysaccharides and its antioxidant activity
    Ai, Songtao
    Fan, Xindong
    Fan, Linfeng
    Sun, Qi
    Liu, Yu
    Tao, Xiaofeng
    Dai, Kerong
    [J]. CARBOHYDRATE POLYMERS, 2013, 94 (02) : 731 - 736
  • [3] Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke
    Arai, Ken
    Jin, Guang
    Navaratna, Deepti
    Lo, Eng H.
    [J]. FEBS JOURNAL, 2009, 276 (17) : 4644 - 4652
  • [4] The protective effect of cordyceps sinensis extract on cerebral ischemic injury via modulating the mitochondrial respiratory chain and inhibiting the mitochondrial apoptotic pathway
    Bai, Xue
    Tan, Tian-Yang
    Li, Yun-Xin
    Li, Yue
    Chen, Ya-Fei
    Ma, Ru
    Wang, Shu-Yan
    Li, Qiang
    Liu, Zhen-Quan
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2020, 124
  • [5] Pathophysiology of cerebral ischemia and brain trauma: Similarities and differences
    Bramlett, HM
    Dietrich, WD
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (02) : 133 - 150
  • [6] Purification, characterization and anticoagulant activity of the polysaccharides from green tea
    Cai, Weirong
    Xie, Liangliang
    Chen, Yong
    Zhang, Hong
    [J]. CARBOHYDRATE POLYMERS, 2013, 92 (02) : 1086 - 1090
  • [7] Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway
    Cao, Shumei
    Du, Jianlong
    Hei, Qiaohong
    [J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (05) : 4919 - 4927
  • [8] Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway
    Che, Nan
    Ma, Yijie
    Xin, Yinhu
    [J]. BIOMOLECULES & THERAPEUTICS, 2017, 25 (03) : 272 - 278
  • [9] Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery
    Chen, Han-sen
    Chen, Xi
    Li, Wen-ting
    Shen, Jian-gang
    [J]. ACTA PHARMACOLOGICA SINICA, 2018, 39 (05) : 669 - 682
  • [10] Effects of polysaccharides of the Euphoria Longan (Lour.) Steud on focal cerebral ischemia/reperfusion injury and its underlying mechanism
    Chen, Jian
    Chen, Xu
    Qin, Jian
    [J]. BRAIN INJURY, 2011, 25 (03) : 292 - 299