Effect of an increased clopidogrel maintenance dose or lansoprazole co-administration on the antiplatelet response to clopidogrel in CYP2C19-genotyped healthy subjects

被引：32

作者：

Hulot, J. -S. ^{[1
,2
,3
]}

Wuerzner, G. ^{[4
]}

Bachelot-Loza, C. ^{[5
]}

Azizi, M. ^{[4
,6
]}

Blanchard, A. ^{[4
]}

Peyrard, S. ^{[4
]}

Funck-Brentano, C. ^{[1
,2
,3
]}

Gaussem, P. ^{[5
,6
,7
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Serv Pharmacol, Unite Pharmacogenet,Ctr Invest Biomed, F-75013 Paris, France

[2] Univ Paris, UPMC, Paris, France

[3] INSERM, UMR S 956, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Ctr Invest Clin, INSERM,CIC 9201, Paris, France

[5] INSERM, UMR S 765, Fac Pharm, Paris, France

[6] Univ Paris 05, Paris, France

[7] Hop Europeen Georges Pompidou, AP HP, Serv Hematol Biol, Paris, France

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2010年 / 8卷 / 03期

关键词：

OF-FUNCTION POLYMORPHISM;

D O I：

10.1111/j.1538-7836.2009.03729.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：610 / 613

页数：4

共 10 条

[1] Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study [J].

Collet, Jean-Philippe ;

Hulot, Jean-Sebastien ;

Pena, Anna ;

Villard, Eric ;

Esteve, Jean-Baptiste ;

Silvain, Johanne ;

Payot, Laurent ;

Brugier, Delphine ;

Cayla, Guillaume ;

Beygui, Farzin ;

Bensimon, Gilbert ;

Funck-Brentano, Christian ;

Montalescot, Gilles .

LANCET, 2009, 373 (9660) :309-317

[2] Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin [J].

Gilard, Martine ;

Arnaud, Bertrand ;

Cornily, Jean-Christophe ;

Le Gal, Gregoire ;

Lacut, Karine ;

Le Calvez, Genevive ;

Mansourati, Jacques ;

Mottier, Dominique ;

Abgrall, Jean-Francois ;

Boschat, Jacques .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (03) :256-260

[3] Cytochrome P4502C19 loss-of-function polymorphism, but not CYP3A4 IVS10+12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients [J].

Giusti, Betti ;

Gori, Anna Maria ;

Marcucci, Rossella ;

Saracini, Claudia ;

Sestini, Ilaria ;

Paniccia, Rita ;

Valente, Serafina ;

Antoniucci, Davide ;

Abbate, Rosanna ;

Gensini, Gian Franco .

PHARMACOGENETICS AND GENOMICS, 2007, 17 (12) :1057-1064

[4] Relation of Cytochrome P450 2C19 Loss-of-Function Polymorphism to Occurrence of Drug-Eluting Coronary Stent Thrombosis [J].

Giusti, Betti ;

Gori, Anna Maria ;

Marcucci, Rossella ;

Saracini, Claudia ;

Sestini, Ilaria ;

Paniccia, Rita ;

Buonamici, Piergiovanni ;

Antoniucci, David ;

Abbate, Rosanna ;

Gensini, Gian Franco .

AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (06) :806-811

[5] Cytochrorne P4502C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects [J].

Hulot, Jean-Sebastien ;

Bura, Alessandra ;

Villard, Eric ;

Azizi, Michel ;

Remones, Veronique ;

Goyenvalle, Catherine ;

Aiach, Martine ;

Lechat, Philippe ;

Gaussem, Pascale .

BLOOD, 2006, 108 (07) :2244-2247

[6] Cytochrome P-450 Polymorphisms and Response to Clopidogrel. [J].

Mega, Jessica L. ;

Close, Sandra L. ;

Wiviott, Stephen D. ;

Shen, Lei ;

Hockett, Richard D. ;

Brandt, John T. ;

Walker, Joseph R. ;

Antman, Elliott M. ;

Macias, William ;

Braunwald, Eugene ;

Sabatine, Marc S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) :354-362

[7] Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials [J].

O'Donoghue, Michelle L. ;

Braunwald, Eugene ;

Antman, Elliott M. ;

Murphy, Sabina A. ;

Bates, Eric R. ;

Rozenman, Yoseph ;

Michelson, Alan D. ;

Hautvast, Raymond W. ;

Lee, Peter N. Ver ;

Close, Sandra L. ;

Shen, Lei ;

Mega, Jessica L. ;

Sabatine, Marc S. ;

Wiviott, Stephen D. .

LANCET, 2009, 374 (9694) :989-997

[8] Can We Override Clopidogrel Resistance? [J].

Pena, Ana ;

Collet, Jean-Philippe ;

Hulot, Jean-Sebastien ;

Silvain, Johanne ;

Barthelemy, Olivier ;

Beygui, Farzin ;

Funck-Brentano, Christian ;

Montalescot, Gilles .

CIRCULATION, 2009, 119 (21) :2854-2857

[9] Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy [J].

Shuldiner, Alan R. ;

O'Connell, Jeffrey R. ;

Bliden, Kevin P. ;

Gandhi, Amish ;

Ryan, Kathleen ;

Horenstein, Richard B. ;

Damcott, Coleen M. ;

Pakyz, Ruth ;

Tantry, Udaya S. ;

Gibson, Quince ;

Pollin, Toni I. ;

Post, Wendy ;

Parsa, Afshin ;

Mitchell, Braxton D. ;

Faraday, Nauder ;

Herzog, William ;

Gurbel, Paul A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (08) :849-858

[10] Genetic Determinants of Response to Clopidogrel and Cardiovascular Events. [J].

Simon, Tabassome ;

Verstuyft, Celine ;

Mary-Krause, Murielle ;

Quteineh, Lina ;

Drouet, Elodie ;

Meneveau, Nicolas ;

Steg, P. Gabriel ;

Ferrieres, Jean ;

Danchin, Nicolas ;

Becquemont, Laurent .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) :363-375

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