Nodal Morphogens

被引：204
作者：
Schier, Alexander F. [1 ]
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Harvard Stem Cell Inst, Ctr Brain Sci,Broad Inst, Cambridge, MA 02138 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2009年 / 1卷 / 05期
关键词：
EMBRYONIC STEM-CELLS; LEFT-RIGHT ASYMMETRY; TGF-BETA SUPERFAMILY; ONE-EYED-PINHEAD; GERM-LAYER SPECIFICATION; OF-FUNCTION MUTATIONS; EARLY MOUSE EMBRYO; LEFT-RIGHT AXIS; EGF-CFC GENES; LONG-RANGE;
D O I：
10.1101/cshperspect.a003459
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, co-receptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.
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页数：20
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