Detection of Lysosome by a Fluorescent Heterocycle: Development of Fused Pyrido-Imidazo-Indole Framework via Cu-Catalyzed Tandem N-Arylation

被引：20

作者：

Banerji, Biswadip ^{[1
,2
]}

Chatterjee, Satadru ^{[1
]}

Chandrasekhar, Kadaiahgari ^{[1
]}

Ghosh, Saswati ^{[1
]}

Mukherjee, Kaustuv ^{[3
]}

Mandal, Chitra ^{[3
]}

机构：

[1] IICB, CSIR, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India

[2] IICB, CSIR, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, India

[3] IICB, CSIR, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 21期

关键词：

INHIBITORS; ANALOGS; POTENT; LUMINOPHORES; ALKYLATION; DISCOVERY; AMINATION; CHEMISTRY; SEQUENCE; DIVERSE;

D O I：

10.1021/acs.joc.8b01513

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorescent active small molecules for organelle-specific bioimaging are in great demand. We synthesized 20 different pyrido-imidazo-indole fused heterocycles (6-5-5-6 ring) via copper catalyzed tandem N-arylation reaction in moderate to good yields. Due to decent fluorescent property, lysosome-directing moieties were attached on two of these heterocycles. Delightfully, those molecules tracked lysosome with bright blue fluorescence and colocalized with a known lysosome marker (Lysotracker Red) in human/murine cells. Therefore, it may be considered as a rapid (10 min) lysosome staining probe.

引用

页码：13011 / 13018

页数：8

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