Immunogenicity of a modified-live virus vaccine against bovine viral diarrhea virus types 1 and 2, infectious bovine rhinotracheitis virus, bovine parainfluenza-3 virus, and bovine respiratory syncytial virus when administered intranasally in young calves

被引：44

作者：

Xue, Wenzhi ^{[1
]}

Ellis, John ^{[2
]}

Mattick, Debra ^{[1
]}

Smith, Linda ^{[1
]}

Brady, Ryan ^{[1
]}

Trigo, Emilio ^{[1
]}

机构：

[1] Intervet Schering Plough Anim Hlth, DeSoto, KS 66018 USA

[2] Univ Saskatchewan, Dept Vet Microbiol, Western Coll Vet Med, Saskatoon, SK S7N 5B4, Canada

来源：

VACCINE | 2010年 / 28卷 / 22期

关键词：

Modified-live virus vaccine; Bovine respiratory diseases; BVDV; IBR; BRSV; PI-3; Intranasal vaccination; FEEDLOT CALVES; DISEASE; CATTLE; RESPONSES; HERPESVIRUS-1; REPLICATION; ASSOCIATION; LYMPHOCYTE; EFFICACY;

D O I：

10.1016/j.vaccine.2010.03.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of an intranasally-administered modified-live virus (MLV) vaccine in 3-8 day old calves was evaluated against bovine viral diarrhea virus (BVDV) types 1 and 2, infectious bovine rhinotracheitis (IBR) virus, parainfluenza-3 (PI-3) virus and bovine respiratory syncytial virus (BRSV). Calves were intranasally vaccinated with a single dose of a multivalent MLV vaccine and were challenged with one of the respective viruses three to four weeks post-vaccination in five separate studies. There was significant sparing of diseases in calves intranasally vaccinated with the MLV vaccine, as indicated by significantly fewer clinical signs, lower rectal temperatures, reduced viral shedding, greater white blood cell and platelet counts, and less severe pulmonary lesions than control animals. This was the first MLV combination vaccine to demonstrate efficacy against BVDV types 1 and 2, IBR, PI-3 and BRSV in calves 3-8 days of age. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3784 / 3792

页数：9

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