The status of diabetic embryopathy

被引：36
作者：
Eriksson, Ulf J. [1 ]
Wentzel, Parri [1 ]
机构：
[1] Uppsala Univ, Biomed Ctr, Dept Med Cell Biol, POB 571, SE-75123 Uppsala, Sweden
来源：
UPSALA JOURNAL OF MEDICAL SCIENCES | 2016年 / 121卷 / 02期
基金：
瑞典研究理事会;
关键词：
Anomalies; development; diabetes in pregnancy; epigenetics; gene expression; malformations; NEURAL-TUBE DEFECTS; CONGENITAL HEART-DEFECTS; ENDOPLASMIC-RETICULUM STRESS; HIGH GLUCOSE-CONCENTRATION; DEPENDENT ANTIOXIDANT SYSTEM; INCREASED LIPID-PEROXIDATION; RADICAL SCAVENGING ENZYMES; GENE-EXPRESSION PROFILES; INDUCED OXIDATIVE STRESS; VISCERAL YOLK-SAC;
D O I：
10.3109/03009734.2016.1165317
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic embryopathy is a theoretical enigma and a clinical challenge. Both type 1 and type 2 diabetic pregnancy carry a significant risk for fetal maldevelopment, and the precise reasons for the diabetes induced teratogenicity are not clearly identified. The experimental work in this field has revealed a partial, however complex, answer to the teratological question, and we will review some of. the latest suggestions.
引用
收藏
页码：96 / 112
页数：17
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