Single-Unit Activity in the Medial Prefrontal Cortex during Immediate and Delayed Extinction of Fear in Rats

被引:90
作者
Chang, Chun-hui [1 ]
Berke, Joshua D. [1 ,2 ]
Maren, Stephen [1 ,2 ]
机构
[1] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
LONG-TERM POTENTIATION; LATERAL AMYGDALA; INFRALIMBIC CORTEX; LEARNED FEAR; NEURONS; MEMORY; CONSOLIDATION; INTERNEURONS; EXCITABILITY; MAINTENANCE;
D O I
10.1371/journal.pone.0011971
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Delivering extinction trials minutes after fear conditioning yields only a short-term fear suppression that fully recovers the following day. Because extinction has been reported to increase CS-evoked spike firing and spontaneous bursting in the infralimbic (IL) division of the medial prefrontal cortex (mPFC), we explored the possibility that this immediate extinction deficit is related to altered mPFC function. Single-units were simultaneously recorded in rats from neurons in IL and the prelimbic (PrL) division of the mPFC during an extinction session conducted 10 minutes (immediate) or 24 hours (delayed) after auditory fear conditioning. In contrast to previous reports, IL neurons exhibited CS-evoked responses early in extinction training in both immediate and delayed conditions and these responses decreased in magnitude over the course of extinction training. During the retention test, CS-evoked firing in IL was significantly greater in animals that failed to acquire extinction. Spontaneous bursting during the extinction and test sessions was also different in the immediate and delayed groups. There were no group differences in PrL activity during extinction or retention testing. Alterations in both spontaneous and CS-evoked neuronal activity in the IL may contribute to the immediate extinction deficit.
引用
收藏
页数:7
相关论文
共 60 条
[1]  
Akirav Irit, 2007, Neural Plasticity, V2007, DOI 10.1155/2007/30873
[2]  
[Anonymous], 1941, Conditioned reflexes and psychiatry
[3]  
Barrett D, 2003, J NEUROSCI, V23, P5740
[4]   Characterization of neocortical principal cells and Interneurons by network interactions and extracellular features [J].
Barthó, P ;
Hirase, H ;
Monconduit, L ;
Zugaro, M ;
Harris, KD ;
Buzsáki, G .
JOURNAL OF NEUROPHYSIOLOGY, 2004, 92 (01) :600-608
[5]   Oscillatory entrainment of striatal neurons in freely moving rats [J].
Berke, JD ;
Okatan, M ;
Skurski, J ;
Eichenbaum, HB .
NEURON, 2004, 43 (06) :883-896
[6]   Randomised controlled trial of psychological debriefing for victims of acute burn trauma [J].
Bisson, JI ;
Jenkins, PL ;
Alexander, J ;
Bannister, C .
BRITISH JOURNAL OF PSYCHIATRY, 1997, 171 :78-81
[7]   Contextual and temporal modulation of extinction: Behavioral and biological mechanisms [J].
Bouton, Mark E. ;
Westbrook, R. Frederick ;
Corcoran, Kevin A. ;
Maren, Stephen .
BIOLOGICAL PSYCHIATRY, 2006, 60 (04) :352-360
[8]   Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex [J].
Burgos-Robles, Anthony ;
Vidal-Gonzalez, Ivan ;
Santini, Edwin ;
Quirk, Gregory J. .
NEURON, 2007, 53 (06) :871-880
[9]   Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure [J].
Burgos-Robles, Anthony ;
Vidal-Gonzalez, Ivan ;
Quirk, Gregory J. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (26) :8474-8482
[10]   Homeostatic maintenance of neuronal excitability by burst discharges in vivo [J].
Buzsáki, G ;
Csicsvari, J ;
Dragoi, G ;
Harris, K ;
Henze, D ;
Hirase, H .
CEREBRAL CORTEX, 2002, 12 (09) :893-899