The association between selenium and lipid levels: A longitudinal study in rural elderly Chinese

被引:41
作者
Chen, Chen [5 ]
Jin, Yinlong [5 ]
Unverzagt, Frederick W. [2 ]
Cheng, Yibin [5 ]
Hake, Ann M. [3 ,4 ]
Liang, Chaoke [5 ]
Ma, Feng [5 ]
Su, Liqin [5 ]
Liu, Jingyi [5 ]
Bian, Jianchao [6 ]
Li, Ping [7 ]
Gao, Sujuan [1 ]
机构
[1] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
[4] Eli Lilly & Co, Indianapolis, IN 46285 USA
[5] Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safety, Beijing, Peoples R China
[6] Shandong Inst Prevent & Treatment Endem Dis China, Jinan, Peoples R China
[7] Sichuan Prov Ctr Dis Control & Prevent China, Chengdu, Peoples R China
基金
美国国家卫生研究院;
关键词
Selenium; Lipids; Elderly Chinese; CORONARY-HEART-DISEASE; SERUM SELENIUM; CARDIOVASCULAR RISK; TOENAIL SELENIUM; COGNITIVE FUNCTION; RANDOMIZED-TRIAL; HUMAN HEALTH; VITAMIN-E; SUPPLEMENTATION; MORTALITY;
D O I
10.1016/j.archger.2014.09.005
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: A protective effect of selenium on lipid levels has been reported in populations with relatively low selenium status. However, recent studies found that high selenium exposure may lead to adverse cardiometabolic effects, particularly in selenium-replete populations. We examined the associations of selenium status with changes in lipid levels in a 7-year follow up of an elderly Chinese cohort including participants from selenium-deplete areas. Methods: Study population consisted of 140 elderly Chinese aged 65 or older with nail selenium levels measured at baseline (2003-2005). Lipid concentrations were measured in fasting blood samples collected at baseline and the 7-year follow-up (2010-2012). Analysis of covariance (ANCOVA) models was used to determine the association between baseline selenium status and changes in lipid levels from baseline to follow-up adjusting for other covariates. Results: Mean (+/- standard deviation) baseline selenium concentration was 0.41 +/- 0.2 mg/kg. In prospective analysis, we found that individuals in the highest selenium quartile group showed 1.11 SD decrease on total-cholesterol (p < 0.001), 0.41 SD increase on HDL-cholesterol (p < 0.001) and 0.52 SD decrease on triglyceride after 7 years than those in the lowest selenium quartile group. The similar trends were seen with significant lipid changes in the 2nd and 3rd quartile groups. Conclusion: Selenium has modest beneficial effects on blood lipid levels in a population with relatively low selenium status. Our result suggests adequate dietary selenium intake as a potential prevention strategy for lowering lipid levels in selenium deplete populations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:147 / 152
页数:6
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