Sulfation of Betulin by Sulfamic Acid in DMF and Dioxane

被引：8
|
作者：
Levdanskii, V. A. [1 ,2 ]
Levdanskii, A. V. [1 ]
Kuznetsov, B. N. [1 ,2 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Krasnoyarsk 660036, Russia
[2] Siberian Fed Univ, Krasnoyarsk 660041, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 06期
关键词：
betulin; 1,4-dioxane; N; N-dimethylformamide; sulfation; betulin 3,28-disulfate; urea; sulfamic acid;
D O I：
10.1007/s10600-014-1152-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Betulin was sulfated by sulfamic acid in the presence of urea in homogeneous solution in 1,4-dioxane or N,N-dimethylformamide (DMF). The reaction time for betulin sulfation in DMF at 60-70A degrees C was 2.0-3.0 h; in 1,4-dioxane at 70-75A degrees C, 3.0-3.5 h. Betulin disulfate was obtained in the acidic form and as the ammonium, sodium, and potassium salts.
引用
收藏
页码：1029 / 1031
页数：3
相关论文
共 50 条
  • [41] SULFAMIC ACID
    SISLER, HH
    BUTLER, MJ
    AUDRIETH, LF
    INORGANIC SYNTHESES, 1946, 2 : 176 - 179
  • [42] Integration of peroxide delignification and sulfamic acid sulfation methods for obtaining cellulose sulfates from aspen wood
    Boris Kuznetsov
    Vladimir Levdansky
    Svetlana Kuznetsova
    Natalya Garyntseva
    Irina Sudakova
    Alexander Levdansky
    European Journal of Wood and Wood Products, 2018, 76 : 999 - 1007
  • [43] REACTION OF THE DIOXANE SULFOTRIOXIDE REAGENT WITH ANILINE - CLASSIFICATION OF THE SULFAMIC ACIDS
    HURD, CD
    KHARASCH, N
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1947, 69 (09) : 2113 - 2115
  • [44] REFINEMENT OF SULFAMIC ACID
    CAMERON, AF
    DUNCANSON, FD
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (MAY15): : 1563 - 1564
  • [45] Sulfonation of Betulinic Acid by Sulfamic Acid
    V. A. Levdanskii
    A. V. Levdanskii
    B. N. Kuznetsov
    Chemistry of Natural Compounds, 2015, 51 : 894 - 896
  • [46] REACTION OF ACID HYDRAZIDES WITH SULFAMIC ACID
    TAKATA, Y
    MATSUDA, T
    YOKOTA, K
    NIPPON KAGAKU ZASSHI, 1961, 82 (03): : 376 - &
  • [47] Sulfonation of Betulinic Acid by Sulfamic Acid
    Levdanskii, V. A.
    Levdanskii, A. V.
    Kuznetsov, B. N.
    CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (05) : 894 - 896
  • [48] THE CONFIGURATION OF UNDISSOCIATED SULFAMIC ACID
    LINGAFELTER, EC
    KELLS, LF
    TARTAR, HV
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (19) : 4973 - 4974
  • [49] HEAT OF FORMATION OF SULFAMIC ACID
    NASH, GA
    SKINNER, HA
    ZORDAN, TA
    HEPLER, LG
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1968, 13 (02): : 271 - &
  • [50] HYDROLYSIS RATE OF SULFAMIC ACID
    NOTLEY, JM
    JOURNAL OF APPLIED CHEMISTRY AND BIOTECHNOLOGY, 1973, 23 (10): : 717 - 723
12345