Sulfation of Betulin by Sulfamic Acid in DMF and Dioxane

被引：8
|
作者：
Levdanskii, V. A. [1 ,2 ]
Levdanskii, A. V. [1 ]
Kuznetsov, B. N. [1 ,2 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Krasnoyarsk 660036, Russia
[2] Siberian Fed Univ, Krasnoyarsk 660041, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 06期
关键词：
betulin; 1,4-dioxane; N; N-dimethylformamide; sulfation; betulin 3,28-disulfate; urea; sulfamic acid;
D O I：
10.1007/s10600-014-1152-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Betulin was sulfated by sulfamic acid in the presence of urea in homogeneous solution in 1,4-dioxane or N,N-dimethylformamide (DMF). The reaction time for betulin sulfation in DMF at 60-70A degrees C was 2.0-3.0 h; in 1,4-dioxane at 70-75A degrees C, 3.0-3.5 h. Betulin disulfate was obtained in the acidic form and as the ammonium, sodium, and potassium salts.
引用
收藏
页码：1029 / 1031
页数：3
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