Sulfation of Betulin by Sulfamic Acid in DMF and Dioxane

被引：8

作者：

Levdanskii, V. A. ^{[1
,2
]}

Levdanskii, A. V. ^{[1
]}

Kuznetsov, B. N. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Krasnoyarsk 660036, Russia

[2] Siberian Fed Univ, Krasnoyarsk 660041, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 06期

关键词：

betulin; 1,4-dioxane; N; N-dimethylformamide; sulfation; betulin 3,28-disulfate; urea; sulfamic acid;

D O I：

10.1007/s10600-014-1152-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Betulin was sulfated by sulfamic acid in the presence of urea in homogeneous solution in 1,4-dioxane or N,N-dimethylformamide (DMF). The reaction time for betulin sulfation in DMF at 60-70A degrees C was 2.0-3.0 h; in 1,4-dioxane at 70-75A degrees C, 3.0-3.5 h. Betulin disulfate was obtained in the acidic form and as the ammonium, sodium, and potassium salts.

引用

页码：1029 / 1031

页数：3

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