Non-Coding RNAs in Endometrial Physiopathology

被引：83

作者：

La Ferlita, Alessandro ^{[1
]}

Battaglia, Rosalia ^{[1
]}

Andronico, Francesca ^{[1
]}

Caruso, Salvatore ^{[2
]}

Cianci, Antonio ^{[2
]}

Purrello, Michele ^{[1
]}

Di Pietro, Cinzia ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Biol & Genet Sect G Sichel, I-95123 Catania, Italy

[2] Univ Catania, Dept Gen Surg & Med Surg Specialties, I-95123 Catania, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期

关键词：

miRNA; lncRNAs; endometrial cancer; endometriosis; chronic endometritis; EPITHELIAL-MESENCHYMAL TRANSITION; EUTOPIC SECRETORY ENDOMETRIUM; PROMOTES CELL-PROLIFERATION; ESTROGEN-RECEPTOR-ALPHA; MUCIN; EXPRESSION; H19 ONCOFETAL RNA; CANCER-CELLS; TUMOR-SUPPRESSOR; PTEN EXPRESSION; DOWN-REGULATION;

D O I：

10.3390/ijms19072120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.

引用

页数：25

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