Synthesis, Characterization and In Vitro Biological Evaluation of Sol-gel Derived Sr-containing Nano Bioactive Glass

被引：41
作者：
Solgi, S. [1 ]
Khakbiz, M. [1 ]
Shahrezaee, M. [2 ]
Zamanian, A. [3 ]
Tahriri, M. [4 ,5 ,6 ,7 ]
Keshtkari, S. [8 ]
Raz, M. [7 ]
Khoshroo, K. [6 ]
Moghadas, S. [9 ]
Rajabnejad, A. [1 ]
机构：
[1] Univ Tehran, Fac New Sci & Technol, Tehran, Iran
[2] AJA Univ Med Sci, Dept Orthoped Surg, Tehran, Iran
[3] Mat & Energy Res Ctr, Nanotechnol & Adv Mat Dept, Karaj, Iran
[4] Tehran Univ Med Sci, Iranian Tissue Bank, Tehran, Iran
[5] Tehran Univ Med Sci, Res Ctr, Tehran, Iran
[6] Tehran Univ Med Sci, Sch Dent, Dent Biomat Dept, Tehran, Iran
[7] Amirkabir Univ Technol, Fac Biomed Engn, Biomat Grp, Tehran, Iran
[8] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran
[9] Mat & Energy Res Ctr, Dept Ceram, Karaj, Iran
来源：
SILICON | 2017年 / 9卷 / 04期
关键词：
Bioactive glass; Strontium; Sol-gel; Osteoblastic cell; SIMULATED BODY-FLUID; ION RELEASE; DIFFERENTIATION; STRONTIUM; CERAMICS; SCAFFOLDS; CELLS; 45S5; MG;
D O I：
10.1007/s12633-015-9291-x
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this study, bioactive glass of the type SiO2-CaO-SrO-P2O5 was obtained by the sol-gel processing method and the effects of SrO/CaO substitution on the in vitro biological properties of the synthesized glasses were evaluated. The obtained bioactive glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), differentioal scanning caloremetry (DSC) and Brunauer, Emmett and Teller (BET) analyses. The effects of various glass compositions on proliferation and differentiation of osteoblastic cells were also evaluated. The results showed that incorporation of Sr in the obtained glass network did not result in any structural alteration due to the similar role of SrO compared with that of CaO. In vitro experiments with human osteosarcoma cell lines (MG-63) indicated that bioactive glass incorporating 5 mol % in the composition revealed optimal cell proliferation and alkaline phosphatase (ALP) activity. Our results ascertained this material to be non-toxic and compatible for the proposed work in segmental defects in the rabbit model in vivo.
引用
收藏
页码：535 / 542
页数：8
相关论文
共 31 条
  • [1] Synthesis and characterisation of sol gel derived bioactive glass for biomedical applications
    Balamurugan, A.
    Sockalingum, G.
    Michel, J.
    Faure, J.
    Banchet, V.
    Wortham, L.
    Bouthors, S.
    Laurent-Maquin, D.
    Balossier, G.
    [J]. MATERIALS LETTERS, 2006, 60 (29-30) : 3752 - 3757
  • [2] Mg- and/or Sr-doped tricalcium phosphate/bioactive glass composites: Synthesis, microstructure and biological responsiveness
    Bellucci, Devis
    Sola, Antonella
    Cacciotti, Ilaria
    Bartoli, Cristina
    Gazzarri, Matteo
    Bianco, Alessandra
    Chiellini, Federica
    Cannillo, Valeria
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 42 : 312 - 324
  • [3] Chatzistavrou X, 2013, WOODH PUBL SER BIOM, V53, P194, DOI 10.1533/9780857096432.2.194
  • [4] A new sol-gel process for producing Na2O-containing bioactive glass ceramics
    Chen, Qi-Zhi
    Li, Yuan
    Jin, Li-Yu
    Quinn, Julian M. W.
    Komesaroff, Paul A.
    [J]. ACTA BIOMATERIALIA, 2010, 6 (10) : 4143 - 4153
  • [5] Bioactivity of tape cast and sintered bioactive glass-ceramic in simulated body fluid
    Clupper, DC
    Mecholsky, JJ
    LaTorre, GP
    Greenspan, DC
    [J]. BIOMATERIALS, 2002, 23 (12) : 2599 - 2606
  • [6] Bioactive glass prepared by sol-gel emulsion
    Delben, J. R. J.
    Pereira, K.
    Oliveira, S. L.
    Alencar, L. D. S.
    Hernandes, A. C.
    Delben, A. A. S. T.
    [J]. JOURNAL OF NON-CRYSTALLINE SOLIDS, 2013, 361 : 119 - 123
  • [7] Diba M., 2014, PRECIOUS METALS BIOM, P177, DOI [DOI 10.1533/9780857099051.2.177, 10.1533/9780857099051.2.177]
  • [8] Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro
    Gentleman, E.
    Stevens, M. M.
    Hill, R. G.
    Brauer, D. S.
    [J]. ACTA BIOMATERIALIA, 2013, 9 (03) : 5771 - 5779
  • [9] The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro
    Gentleman, Eileen
    Fredholm, Yann C.
    Jell, Gavin
    Lotfibakhshaiesh, Nasrin
    O'Donnell, Matthew D.
    Hill, Robert G.
    Stevens, Molly M.
    [J]. BIOMATERIALS, 2010, 31 (14) : 3949 - 3956
  • [10] In vitro reactivity of Sr-containing bioactive glass (type 1393) nanoparticles
    Hoppe, A.
    Sarker, B.
    Detsch, R.
    Hild, N.
    Mohn, D.
    Stark, W. J.
    Boccaccini, A. R.
    [J]. JOURNAL OF NON-CRYSTALLINE SOLIDS, 2014, 387 : 41 - 46
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