malignant blue nevus;
atypical blue nevus;
melanoma;
MUTATIONS;
D O I:
10.1097/DAD.0000000000001913
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Histologic distinction between melanoma ex-blue nevus and cellular blue nevus (CBN) can often be difficult, but features supporting melanoma include infiltrative growth pattern, frequent mitoses, cytologic atypia and pleomorphism, cell crowding, and tumor necrosis. Unfortunately, these features are not constantly dependable and frequently borderline lesions exist, so-called atypical CBN, which lack explicit malignant features. Furthermore, some CBN and atypical CBN show an assortment of features, which may lead to their misdiagnosis as melanoma, but to date necrosis is generally absent. We present an unusual case of an atypical cellular blue nevus with extensive necrosis mimicking melanoma ex-blue nevus.
机构:
Tianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R China
He, Tiangeng
Mao, Chunjie
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机构:
Tianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R China
Mao, Chunjie
Xu, Dongbo
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机构:
Tianjin Med Univ, Gen Hosp, Dept Pathol, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R China
Xu, Dongbo
Yan, Hua
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机构:
Tianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ, Gen Hosp, Dept Ophthalmol, 154 Anshan Rd, Tianjin 300052, Peoples R China