Synthesis, Crystal Structure and Antiproliferative Activity of 6-Adamantyl-3-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

被引：13

作者：

Khan, Mahmood-ul-Hassan ^{[1
]}

Akhtar, Tashfeen ^{[1
]}

Yasin, Khawaja A. ^{[1
]}

Al-Masoudi, Najim A. ^{[2
]}

Jones, Peter G. ^{[3
]}

Hameed, Shahid ^{[1
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Univ Basrah, Coll Sci, Dept Chem, Basrah, Iraq

[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2010年 / 65卷 / 02期

关键词：

Antiproliferative Activity; 1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles; Adamantyl Derivatives; ANTIMICROBIAL ACTIVITIES; ANTIINFLAMMATORY ACTIVITIES; HETEROCYCLIC-SYSTEMS; UREASE INHIBITION; DERIVATIVES; ANTITUMOR; ANALOGS; AGENTS;

D O I：

10.1515/znb-2010-0214

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a-1 bearing an adamantyl moiety were synthesized by condensation of 4-amino-5-aryl-2H-1,2,4-triazole-3(4H)-thiones 4a-1 with adamantyl-l-carboxylic acid in the presence of POCl(3). The structures of the newly synthesized compounds were established using spectroanalytical techniques and verified further by the crystal structure determination of compounds 5a and 5j. The compounds were screened for their antiproliferative activity against a large panel of human cell lines.

引用

页码：178 / 184

页数：7

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