Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents

被引：46
作者：
Gupta, Leena
Talwar, Archna
Nishi
Palne, Shraddha
Gupta, Suman
Chauhan, Prern M. S. [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Isabella Thouborn PG Coll, Dept Chem, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 14期
关键词：
Leishmania; dihydrocoscinamide B; indolylglyoxylamides;
D O I：
10.1016/j.bmcl.2007.04.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of marine alkaloid 8,9-dihydrocoseinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 mu g/ml. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：4075 / 4079
页数：5
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