Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?

被引：6
作者：
Zhang, Zeli [1 ]
Gu, Qinyong [1 ]
Marino, Daniela [1 ]
Lee, Kyeong-Lim [2 ]
Kong, Il-Keun [2 ]
Haeussinger, Dieter [1 ]
Muenk, Carsten [1 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Fac Med, Clin Gastroenterol Hepatol & Infectiol, D-40225 Dusseldorf, Germany
[2] Gyeongsang Natl Univ, Grad Sch, Div Appl Life Sci BK21Plus, Jinju 52828, South Korea
来源：
VIRUSES-BASEL | 2018年 / 10卷 / 04期
关键词：
FIV; restriction factors; feline APOBEC3; cross-species transmission; IMMUNODEFICIENCY VIRUS VIF; HIV-1 REVERSE TRANSCRIPTION; PROTEINS REGULATE AUTOPHAGY; AMINO-ACID-RESIDUES; CD4(+) T-CELLS; LENTIVIRAL VIF; DOMESTIC CATS; ANTIRETROVIRAL ACTIVITY; RESTRICTION FACTORS; LEUKEMIA-VIRUS;
D O I：
10.3390/v10040186
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified. Feline immunodeficiency virus (FMV) was found to be sensitive to several feline cellular restriction factors, such as apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) and tetherin, but FIV evolved to counteract them. Here, we describe the molecular mechanisms by which feline APOBEC3 restriction factors inhibit FIV replication and discuss the molecular interaction of APOBEC3 proteins with the viral antagonizing protein Vif. We speculate that feline APOBEC3 proteins could explain some of the observed FIV cross-species transmissions described in wild Felids.
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页数：16
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