Provisioning the origin and early evolution of life

被引:32
|
作者
Wu, Long-Fei [1 ]
Sutherland, John D. [1 ]
机构
[1] Med Res Council Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England
基金
英国医学研究理事会;
关键词
CATALYSIS; PURINE; ENZYME; ACID; RNA; INTERMEDIATE; NUCLEOBASES; DEGRADATION; SYNTHETASE; NUCLEOTIDE;
D O I
10.1042/ETLS20190011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is a lot of controversy in the origin and early evolution of life field, but most people agree that at the advent of genetically coded protein synthesis, cells must have had access to ribonucleotides, amino acids, lipids and some sort of energy source. However, the provenance of these materials is a contentious issue - did early life obtain its building blocks prefabricated from the environment, or did it synthesise them from feedstocks such as CO2 and N-2? In the first case, synthesis conditions need not have been compatible with life and any kind of reaction network that furnished the building blocks - and not much else - could have provisioned the subsequent origin and early evolution of life. In the second case, synthesis must have been under life-compatible conditions, with the reaction network either along the same lines as extant biology or along different ones. On the basis of experimental evidence, we will argue in favour of prefabrication and against synthesis by life in its nascent state, especially synthesis that resembles extant biosynthesis, which we suggest would have been well-nigh impossible without biological catalysts.
引用
收藏
页码:459 / 468
页数:10
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