Precision oncology: separating the wheat from the chaff

被引：31
|
作者：
Remon, Jordi [1 ]
Dienstmann, Rodrigo [2 ]
机构：
[1] HM Delfos, Ctr Integral Oncol Clara Campal Barcelona, Med Oncol Dept, Barcelona, Spain
[2] Hosp Valle De Hebron, Oncol Data Sci ODysSey Grp, Barcelona, Spain
来源：
ESMO OPEN | 2018年 / 3卷 / 06期
关键词：
CELL LUNG-CANCER; METASTATIC BREAST-CANCER; OPEN-LABEL; MOLECULAR CHARACTERIZATION; ANTICANCER DRUGS; TARGETED THERAPY; FDA APPROVAL; SOLID TUMORS; PHASE-II; MEDICINE;
D O I：
10.1136/esmoopen-2018-000446
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients' outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Precision medicine in pediatric oncology
    Forrest, Suzanne J.
    Geoerger, Birgit
    Janeway, Katherine A.
    CURRENT OPINION IN PEDIATRICS, 2018, 30 (01) : 17 - 24
  • [22] Precision Medicine in Pediatric Oncology
    Vo, Kieuhoa T.
    Parsons, D. Williams
    Seibel, Nita L.
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2020, 29 (01) : 63 - +
  • [23] Precision oncology in Latin America: current situation, challenges and perspectives
    Calderon-Auaricio, Ali
    Orue, Andrea
    ECANCERMEDICALSCIENCE, 2019, 13
  • [24] Patient-centric trials for therapeutic development in precision oncology
    Biankin, Andrew V.
    Piantadosi, Steven
    Hollingsworth, Simon J.
    NATURE, 2015, 526 (7573) : 361 - 370
  • [25] Precision medicine in pediatric oncology: Lessons learned and next steps
    Mody, Rajen J.
    Prensner, John R.
    Everett, Jessica
    Parsons, D. Williams
    Chinnaiyan, Arul M.
    PEDIATRIC BLOOD & CANCER, 2017, 64 (03)
  • [26] The evolving landscape of tissue-agnostic therapies in precision oncology
    Subbiah, Vivek
    Gouda, Mohamed A.
    Ryll, Bettina
    Burris, Howard A.
    Kurzrock, Razelle
    CA-A CANCER JOURNAL FOR CLINICIANS, 2024, 74 (05) : 433 - 452
  • [27] Precision Oncology in Sarcomas: Divide and Conquer
    Pestana, Roberto Carmagnani
    Groisberg, Roman
    Roszik, Jason
    Subbiah, Vivek
    JCO PRECISION ONCOLOGY, 2019, 3 : 1 - 16
  • [28] Understanding inequities in precision oncology diagnostics
    Dutta, Ritika
    Vallurupalli, Mounica
    McVeigh, Quinn
    Huang, Franklin W.
    Rebbeck, Timothy R.
    NATURE CANCER, 2023, 4 (06) : 787 - 794
  • [29] Delivering precision oncology to patients with cancer
    Mateo, Joaquin
    Steuten, Lotte
    Aftimos, Philippe
    Andre, Fabrice
    Davies, Mark
    Garralda, Elena
    Geissler, Jan
    Husereau, Don
    Martinez-Lopez, Iciar
    Normanno, Nicola
    Reis-Filho, Jorge S.
    Stefani, Stephen
    Thomas, David M.
    Westphalen, C. Benedikt
    Voest, Emile
    NATURE MEDICINE, 2022, 28 (04) : 658 - 665
  • [30] Precision Oncology in Melanoma: Changing Practices
    Dougherty, Sean C.
    Flowers, William L.
    Gaughan, Elizabeth M.
    JOURNAL OF NUCLEAR MEDICINE, 2024, 65 (12) : 1838 - 1845
12345