Cucurbitacins from Bacopa monnieri

被引:45
作者
Bhandari, Pamita [1 ]
Kumar, Neeraj [1 ]
Singh, Bikram [1 ]
Kaul, Vijay K. [1 ]
机构
[1] Inst Himalayan Bioresource Technol, Nat Plant Prod Div, Palampur 176061, HP, India
关键词
Bacopa monnieri; Scrophulariaceae; cucurbitacins; bacobitacin A-D; ESI-QTOF-MS;
D O I
10.1016/j.phytochem.2007.03.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Four cucurbitacins, bacobitacin A-D (1-4) as well as, a known cytotoxic, cucurbitacin E (5) together with three known phenylethanoid glycosides, monnieraside I, III and plantioside B were isolated form the aerial part of Bacopa monnieri. Their structures were elucidated on the basis of extensive spectroscopic investigations (1D, 2D NMR and ESI-QTOF-MS/MS). This is the first report on the characterization of cucurbitacins in B. monnieri. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1248 / 1254
页数:7
相关论文
共 24 条
  • [1] Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of Bacoside A
    Anbarasi, K
    Vani, G
    Balakrishna, K
    Devi, CSS
    [J]. VASCULAR PHARMACOLOGY, 2005, 42 (02) : 57 - 61
  • [2] Bacosterol glycoside, 2 new 13,14-seco-steiroid glycoside from Bacopa monnieri
    Bhandari, P
    Kumar, N
    Singh, B
    Kaul, VK
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (02) : 240 - 241
  • [3] New phenylethanoid glycosides from Bacopa monniera
    Chakravarty, AK
    Sarkar, T
    Nakane, T
    Kawahara, N
    Masuda, K
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (12) : 1616 - 1618
  • [4] HIGH-FIELD H-1-NMR SPECTRAL-ANALYSIS OF SOME CUCURBITACINS
    CHE, CT
    FANG, XD
    PHOEBE, CH
    KINGHORN, AD
    FARNSWORTH, NR
    YELLIN, B
    HECHT, SM
    [J]. JOURNAL OF NATURAL PRODUCTS, 1985, 48 (03): : 429 - 434
  • [5] The need for establishing identities of 'bacoside A and B', the putative major bioactive saponins of Indian medicinal plant Bacopa monnieri
    Deepak, A
    Amit, A
    [J]. PHYTOMEDICINE, 2004, 11 (2-3) : 264 - 268
  • [6] Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC
    Deepak, M
    Sangli, GK
    Arun, PC
    Amit, A
    [J]. PHYTOCHEMICAL ANALYSIS, 2005, 16 (01) : 24 - 29
  • [7] Bacopasaponin D - A pseudojujubogenin glycoside from Bacopa monniera
    Garai, S
    Mahato, SB
    Ohtani, K
    Yamasaki, K
    [J]. PHYTOCHEMISTRY, 1996, 43 (02) : 447 - 449
  • [8] Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
    Jayaprakasam, B
    Seeram, NP
    Nair, MG
    [J]. CANCER LETTERS, 2003, 189 (01) : 11 - 16
  • [9] Cucurbitane, hexanorcucurbitane and octanorcucurbitane glycosides from fruits of Trichosanthes tricuspidata
    Kanchanapoom, T
    Kasai, R
    Yamasaki, K
    [J]. PHYTOCHEMISTRY, 2002, 59 (02) : 215 - 228
  • [10] Kapoor L. D., 1990, Handbook of ayurvedic medicinal plant