Development of Apremilast Nanoemulsion-Loaded Chitosan Gels: In Vitro Evaluations and Anti-Inflammatory and Wound Healing Studies on a Rat Model

被引：22

作者：

Ahmed, Mohammed Muqtader ^{[1
]}

Anwer, Md Khalid ^{[1
]}

Fatima, Farhat ^{[1
]}

Alali, Amer S. ^{[1
]}

Abul Kalam, Mohd ^{[2
,3
]}

Zafar, Ameeduzzafar ^{[4
]}

Alshehri, Sultan ^{[3
,5
]}

Ghoneim, Mohammed M. ^{[5
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, POB 173, Al Kharj 11942, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, Nanobiotechnol Unit, POB 2457, Riyadh 11451, Saudi Arabia

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia

[4] Jouf Univ, Coll Pharm, Dept Pharmaceut, Sakaka 72341, Aljouf Region, Saudi Arabia

[5] Almaarefa Univ, Coll Pharm, Dept Pharm Practice, Ad Diriyah 13713, Saudi Arabia

来源：

GELS | 2022年 / 8卷 / 05期

关键词：

apremilast; nanoemulsion; chitosan; gels; stability; anti-inflammatory; wound healing; DRUG-DELIVERY SYSTEM; DISSOLUTION; SOLUBILITY; DISEASES; RELEASE;

D O I：

10.3390/gels8050253

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Apremilast (APL) has profound anti-inflammatory and wound healing activity, alongside other dermal care. This study aims to develop APL-loaded NEs (ANE1-ANE5) using eucalyptus oil (EO) as the oil and Tween-80 and transcutol-HP (THP) as a surfactant and co-surfactant, respectively. The prepared NEs were then evaluated based on mean droplet size (12.63 +/- 1.2 nm), PDI (0.269 +/- 0.012), ZP (-23.00 +/- 5.86), RI (1.315 +/- 0.02), and %T (99.89 +/- 0.38) and ANE4 was optimized. Further, optimized NEs (ANE4) were incorporated into chitosan gel (2%, w/v). The developed ANE4-loaded chitosan gel was then evaluated for pH, spreadability, in vitro diffusion, and wound healing and anti-inflammatory studies. Moreover, in vivo studies denoted improved anti-inflammatory and wound healing activity and represented a decrease in wound size percentage (99.68 +/- 0.345%) for the APNE2 gel test compared to a negative control (86.48 +/- 0.87%) and standard control (92.82 +/- 0.34%). Thus, the formulation of ANE4-loaded chitosan gels is an efficient topical treatment strategy for inflammatory and wound healing conditions.

引用

页数：17

共 49 条

[1] Solid-Nanoemulsion Preconcentrate for Oral Delivery of Paclitaxel: Formulation Design, Biodistribution, and γ Scintigraphy Imaging [J].