Cervical Human Papillomavirus Infection (HPV) and High Oncogenic Risk Genotypes among Women Living with HIV in Asia: A Meta-Analysis

被引:13
作者
Verrier, Florian [1 ,2 ,3 ]
Le Coeur, Sophie [1 ,2 ,3 ]
Delory, Tristan [1 ,2 ,3 ,4 ]
机构
[1] Chiang Mai Univ, Fac Associated Med Sci, Chiang Mai 50200, Thailand
[2] Inst Natl Etud Demog INED, 9 Cours Humanites, F-93322 Aubervilliers, France
[3] Inst Rech Dev IRD, UMI 174, PHPT, F-13002 Marseille, France
[4] Ctr Hosp Annecy Genevois, Delegat Rech Clin & Innovat DRCI, F-74370 Epargny Metz Tessy, France
关键词
women; HIV; HPV; oncogenic HPV; Asia; systematic review; meta-analysis; prevalence; HUMAN-IMMUNODEFICIENCY-VIRUS; POSITIVE WOMEN; CANCER; PREVALENCE; POPULATION; LESIONS;
D O I
10.3390/jcm10091911
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Women living with HIV (WLHIV) are prone to harbor several high-risk human papillomavirus (HR-HPV) genotypes and to develop cervical cancerous lesions. Data on HPV prevalence in these women are needed to inform immunization programs, especially in Asia where few data are available. We conducted a systematic review and meta-analysis to estimate the prevalence of HPV and HR-HPV cervical infection in WLHIV in Asia and identify possible sources of heterogeneity for HR-HPV carriage. Pooled prevalence and its 95% confidence interval (95CI) were estimated using the inverse-variance weighting method. Linear regression weighted on study size was used to identify sources of heterogeneity. Among 7834 WLHIV (40 studies), the prevalence of HPV infection was 42.6% (95CI, 38.2% to 47.1%), and 34.6% (95CI, 30.3% to 39.1%) harbored HR-HPV genotypes, with significant heterogeneity across countries. In India, Thailand, and China, HPV-16 was the most frequent genotype (10.3%), followed by HPV-52 (5.4%), HPV-58 (5.0%), HPV-18 (4.1%), and HPV-33 (3.3%). In these women, most of whom were receiving antiretroviral therapy, we did not identify determinants of heterogeneity for HR-HPV infection. Our results underline the need for immunization programs based on nonavalent or new generation vaccines to prevent cervical cancer in WLHIV in Asia.
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页数:12
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