Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue

被引：96

作者：

Hayry, V. ^{[2
,3
]}

Makinen, L. K. ^{[2
]}

Atula, T. ^{[2
]}

Sariola, H. ^{[3
]}

Makitie, A. ^{[2
]}

Leivo, I. ^{[1
]}

Keski-Santti, H. ^{[2
]}

Lundin, J. ^{[4
]}

Haglund, C. ^{[5
]}

Hagstrom, J. ^{[1
,6
]}

机构：

[1] Univ Helsinki, Dept Pathol, Haartman Inst, Helsinki 00014, Finland

[2] Univ Helsinki, Cent Hosp, Dept Otolaryngol Head & Neck Surg, FIN-00290 Helsinki, Hus, Finland

[3] Univ Helsinki, Inst Biomed, Dept Dev Biol, FIN-00014 Helsinki, Finland

[4] Univ Helsinki, Cent Hosp, Dept Oncol, FIN-00290 Helsinki, Hus, Finland

[5] Univ Helsinki, Cent Hosp, Dept Gen Surg, FIN-00290 Helsinki, Hus, Finland

[6] Univ Helsinki, Dept Oral Pathol, Inst Dent, FIN-00014 Helsinki, Finland

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 102卷 / 05期

关键词：

Bmi-1; c-myc; Snail; oral cancer; prognosis; immunohistochemistry; EPITHELIAL-MESENCHYMAL TRANSITION; C-MYC; ORAL TONGUE; GENE-EXPRESSION; POOR-PROGNOSIS; SURVIVAL; CANCER; SNAIL; NECK; TUMORIGENESIS;

D O I：

10.1038/sj.bjc.6605544

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer types. METHODS: Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above. RESULTS: A significant correlation between Bmi-1 protein expression and recurrence (log-rank test, P = 0.005) was detected. Snail and c-myc expression did not correlate with prognosis. Snail expression correlated with histopathological grade (Fisher's exact test, P = 0.007) and with the invasion depth of tumours (chi(2)-test, P = 0.037). CONCLUSION: Negative Bmi-1 immunoexpression might serve as a marker of poor prognosis in oral tongue carcinoma patients. British Journal of Cancer (2010) 102, 892-897. doi: 10.1038/sj.bjc.6605544 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK

引用

页码：892 / 897

页数：6

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