Measurement and prediction of solubilities of active pharmaceutical ingredients

被引：88

作者：

Hahnenkamp, Inga ^{[1
]}

Graubner, Gitte ^{[1
]}

Gmehling, Juergen ^{[1
]}

机构：

[1] Carl VonOssietzky Univ Oldenburg, D-26111 Oldenburg, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2010年 / 388卷 / 1-2期

关键词：

Active pharmaceutical ingredients; Solid-liquid equilibrium; UNIFAC; Mod. UNIFAC (Do); COSMO-RS (Ol); DIFFERENTIAL SCANNING CALORIMETRY; MODIFIED UNIFAC MODEL; LIQUID-EQUILIBRIA; SOLVENTS; EXTENSION; REVISION; MIXTURES;

D O I：

10.1016/j.ijpharm.2009.12.036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solubilities of 2-acetoxy benzoic acid (aspirin), N-acetyl-p-aminophenol (paracetamol) and 2-(p-isobutylphenyl)propionic acid (ibuprofen) have been measured in various solvents and compared with published and predicted data. For the prediction besides the two group contribution models UNIFAC and modified UNIFAC (Dortmund) the quantum chemical approach COSMO-RS (01) was used. Additionally melting temperatures and heats of fusion for 2-acetoxy benzoic acid, N-acetyl-p-aminophenol and 2-(p-isobutylphenyl)propionic acid required for the calculations have been determined by differential scanning calorimetry. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：73 / 81

页数：9

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