Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis

被引：15
作者：
Hinney, Bernd [1 ]
Walter, Anna [1 ]
Aghlmandi, Soheila [2 ]
Andreou, Christina [1 ]
Borgwardt, Stefan [1 ]
机构：
[1] Univ Basel, Dept Psychiat UPK, Basel, Switzerland
[2] Univ Hosp Basel, Basel Inst Clin Epidemiol & Biostat, Basel, Switzerland
来源：
FRONTIERS IN PSYCHIATRY | 2021年 / 11卷
关键词：
schizophrenia; psychosis; hippocampus; neuroimaging; high risk; at-risk mental state; ULTRA-HIGH-RISK; CLINICAL HIGH-RISK; ANTIPSYCHOTIC-NAIVE SCHIZOPHRENIA; 1ST-EPISODE SCHIZOPHRENIA; BRAIN VOLUME; CORTICAL THICKNESS; INDIVIDUALS; ONSET; YOUTH; ABNORMALITIES;
D O I：
10.3389/fpsyt.2020.614659
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Schizophrenia has a prodromal phase of several years in most patients, making it possible to identify patients at clinical high risk (CHR) for developing the disorder. So far, these individuals are identified based on clinical criteria alone, and there is no reliable biomarker for predicting the transition to psychosis. It is well-established that reductions in brain volume, especially in the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume may serve as a biomarker for psychosis. Several studies have already investigated hippocampal volume in CHR groups. Based on these studies, the present meta-analysis compares the baseline left and right hippocampal volume of CHR patients who developed a psychosis with that of CHR patients without such a transition. Our results show no statistically significant effect of the hippocampal volume on the transition risk for psychosis.
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页数：10
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