Iron(II) and zinc(II) complexes with designed pybox ligand for asymmetric aqueous Mukaiyama-aldol reactions

被引：68

作者：

Jankowska, Joanna ^{[1
]}

Paradowska, Joanna ^{[1
]}

Rakiel, Bartosz ^{[1
]}

Mlynarski, Jacek ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 06期

关键词：

D O I：

10.1021/jo0621470

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iron(II) complex with a hindered hydroxyethyl-pybox (hepybox) ligand shows improved catalytic activity and enantioselectivity for asymmetric Mukaiyama-aldol reactions in aqueous media. This water-stable chiral Lewis acid promotes condensation of aromatic silyl enol ethers with a range of aldehydes with good yields, excellent syn-diastereoselectivity and up to 92% ee. The combination of the same ligand with Zn-II salt is also demonstrated as a remarkably efficient and water-compatible chiral Lewis acid.

引用

页码：2228 / 2231

页数：4

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