A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes

被引：8

作者：

Kikuchi, Ryohei ^{[1
,2
]}

Sukhbaatar, Ariunbuyan ^{[1
,2
,3
]}

Sakamoto, Maya ^{[4
]}

Mori, Shiro ^{[1
,2
,5
]}

Kodama, Tetsuya ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Biomed Engn, Lab Biomed Engn Canc, Aoba Ku, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Biomed Engn Canc Res Ctr, Grad Sch Biomed Engn, Aoba Ku, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan

[3] Tohoku Univ, Grad Sch Dent, Dept Oral & Maxillofacial Surg, Aoba Ku, 1-1 Seiryo, Sendai, Miyagi 9808575, Japan

[4] Tohoku Univ Hosp, Dept Oral Diag, Aoba Ku, 1-1 Seiryo, Sendai, Miyagi 9808574, Japan

[5] Tohoku Univ Hosp, Dept Oral & Maxillofacial Surg, Aoba Ku, 1-1 Seiryo, Sendai, Miyagi 9808574, Japan

来源：

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | 2020年 / 20卷

关键词：

Radiation; Mouse model; Lymph node; Metastasis; Abscopal effect; AUTOIMMUNE-DISEASES; MOUSE MODEL; STRATEGY; VESSELS;

D O I：

10.1016/j.ctro.2019.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

引用

页码：53 / 57

页数：5

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