Single Hepatocellular Carcinoma Smaller than 2 cm: Are Ethanol Injection and Radiofrequency Ablation Equally Effective?

被引：2

作者：

Pompili, Maurizio ^{[1
]}

De Matthaeis, Nicoletta ^{[1
]}

Saviano, Antonio ^{[1
]}

De Sio, Ilario ^{[2
]}

Francica, Giampiero ^{[3
]}

Brunello, Franco ^{[4
]}

Cantamessa, Alessandro ^{[4
]}

Giorgio, Antonio ^{[5
]}

Scognamiglio, Umberto ^{[5
]}

Fornari, Fabio ^{[6
]}

Giangregorio, Francesco ^{[6
]}

Piscaglia, Fabio ^{[7
]}

Gualandi, Silvia ^{[7
]}

Caturelli, Eugenio ^{[8
]}

Roselli, Paola ^{[8
]}

Riccardi, Laura ^{[1
]}

Rapaccini, Gian Ludovico ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Internal Med, Rome, Italy

[2] Univ Naples Federico II, Naples, Italy

[3] Pineta Grande Hosp, Diagnost & Intervent Ultrasound Unit, Castel Volturno, Italy

[4] San Giovanni Battista Hosp, Dept Hepatol & Gastroenterol, Turin, Italy

[5] D Cotugno Hosp, Infect Dis & Intervent Ultrasound Unit 9, Naples, Italy

[6] Guglielmo da Saliceto Hosp, Piacenza, Italy

[7] St Orsola Marcello Malpighi Hosp, Bologna, Italy

[8] Belcolle Hosp, Viterbo, Italy

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 01期

关键词：

Hepatocellular carcinoma; liver cirrhosis; percutaneous ethanol injection; radiofrequency ablation; overall survival; tumor recurrence; RANDOMIZED CONTROLLED-TRIAL; ACETIC-ACID INJECTION; CIRRHOTIC-PATIENTS; THERMAL ABLATION; MANAGEMENT; PROGNOSIS; RESECTION; OUTCOMES; THERAPY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC cm. Patients and Methods: Two hundred forty-four cirrhotics with single HCC cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis. Results: The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group. Conclusion: PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

引用

页码：325 / 332

页数：8

共 29 条

[1] Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan [J].

Arii, S ;

Yamaoka, Y ;

Futagawa, S ;

Inoue, K ;

Kobayashi, K ;

Kojiro, M ;

Makuuchi, M ;

Nakamura, Y ;

Okita, K ;

Yamada, R .

HEPATOLOGY, 2000, 32 (06) :1224-1229

[2] Management of hepatoceullular carcinoma [J].

Bruix, J ;

Sherman, M .

HEPATOLOGY, 2005, 42 (05) :1208-1236

[3] Clinical management of hepatocellular carcinoma.: Conclusions of the Barcelona-2000 EASL Conference [J].

Bruix, J ;

Sherman, M ;

Llovet, JM ;

Beaugrand, M ;

Lencioni, R ;

Burroughs, AK ;

Christensen, E ;

Pagliaro, L ;

Colombo, M ;

Rodés, J .

JOURNAL OF HEPATOLOGY, 2001, 35 (03) :421-430

[4] Management of Hepatocellular Carcinoma: An Update [J].

Bruix, Jordi ;

Sherman, Morris .

HEPATOLOGY, 2011, 53 (03) :1020-1022

[5] Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trial [J].

Brunello, Franco ;

Veltri, Andrea ;

Carucci, Patrizia ;

Pagano, Eva ;

Ciccone, Giovannino ;

Moretto, Paolo ;

Sacchetto, Paola ;

Gandini, Giovanni ;

Rizzetto, Mario .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2008, 43 (06) :727-735

[6] Percutaneous ethanol injection for small hepatocellular carcinoma: Therapeutic efficacy based on 20-year observation [J].

Ebara, M ;

Okabe, S ;

Kita, K ;

Sugiura, N ;

Fukuda, H ;

Yoshikawa, M ;

Kondo, F ;

Saisho, H .

JOURNAL OF HEPATOLOGY, 2005, 43 (03) :458-464

[7]

EDMONDSON HA, 1954, CANCER-AM CANCER SOC, V7, P462, DOI 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO

[8]

2-E

[9]

European Assoc Study Liver, 2012, EUR J CANCER, V48, P599, DOI [10.1016/j.jhep.2011.12.001, 10.1016/j.ejca.2011.12.021]

[10] Long-term effectiveness of Radiofrequency Ablation for solitary small Hepatocellular Carcinoma: A retrospective analysis of 363 patients [J].

Francica, Giampiero ;

Saviano, Antonio ;

De Sio, Ilario ;

De Matthaeis, Nicoletta ;

Brunello, Franco ;

Cantamessa, Alessandro ;

Giorgio, Antonio ;

Scognamiglio, Umberto ;

Fornari, Fabio ;

Giangregorio, Francesco ;

Piscaglia, Fabio ;

Gualandi, Silvia ;

Caturelli, Eugenio ;

Roselli, Paola ;

Rapaccini, Gian Ludovico ;

Pompili, Maurizio .

DIGESTIVE AND LIVER DISEASE, 2013, 45 (04) :336-341

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