The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities

被引：8
|
作者：
Bernt, Kathrin M. [1 ]
Hunger, Stephen P. [2 ]
Neff, Tobias [1 ]
机构：
[1] Univ Colorado, Dept Pediat, Ctr Canc & Blood Disorders, Childrens Hosp Colorado, Denver, CO 80202 USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA
来源：
FRONTIERS IN PEDIATRICS | 2016年 / 4卷
关键词：
leukemia; lymphoid; epigenetics; polycomb repressive complex; Hox genes; JAK/STAT signaling pathway; METHYLTRANSFERASE GENE EZH2; SOMATIC MUTATIONS; SWI/SNF COMPLEXES; SELF-RENEWAL; POLYCOMB; EXPRESSION; DNMT3A; LEUKEMIA/LYMPHOMA; DIFFERENTIATION; TRANSFORMATION;
D O I：
10.3389/fped.2016.00049
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.
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页数：7
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