The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities

被引：8
|
作者：
Bernt, Kathrin M. [1 ]
Hunger, Stephen P. [2 ]
Neff, Tobias [1 ]
机构：
[1] Univ Colorado, Dept Pediat, Ctr Canc & Blood Disorders, Childrens Hosp Colorado, Denver, CO 80202 USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA
来源：
FRONTIERS IN PEDIATRICS | 2016年 / 4卷
关键词：
leukemia; lymphoid; epigenetics; polycomb repressive complex; Hox genes; JAK/STAT signaling pathway; METHYLTRANSFERASE GENE EZH2; SOMATIC MUTATIONS; SWI/SNF COMPLEXES; SELF-RENEWAL; POLYCOMB; EXPRESSION; DNMT3A; LEUKEMIA/LYMPHOMA; DIFFERENTIATION; TRANSFORMATION;
D O I：
10.3389/fped.2016.00049
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Emerging Necessity of Myeloid Mutational Analysis in Early T-cell Precursor Acute Lymphoblastic Leukemia/Lymphoma (ETP-ALL)
    Tariq, Hamza
    Shetty, Sindhu
    TURKISH JOURNAL OF HEMATOLOGY, 2023, 40 (03) : 227 - 229
  • [2] Computational modeling of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) to identify personalized therapy using genomics
    Kumar, Ansu
    Drusbosky, Leylah M.
    Meacham, Amy
    Turcotte, Madeleine
    Bhargav, Priyanka
    Vasista, Sumanth
    Usmani, Shahabuddin
    Pampana, Anusha
    Basu, Kabya
    Tyagi, Anuj
    Lala, Deepak
    Rajagopalan, Swaminathan
    Birajdar, Shivgonda C.
    Alam, Aftab
    Roy, Kunal Ghosh
    Abbasi, Taher
    Vali, Shireen
    Sengar, Manju
    Chinnaswamy, Girish
    Shah, Bijal D.
    Cogle, Christopher R.
    LEUKEMIA RESEARCH, 2019, 78 : 3 - 11
  • [3] Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype
    Jain, Nitin
    Lamb, Audrey V.
    O'Brien, Susan
    Ravandi, Farhad
    Konopleva, Marina
    Jabbour, Elias
    Zuo, Zhuang
    Jorgensen, Jeffrey
    Lin, Pei
    Pierce, Sherry
    Thomas, Deborah
    Rytting, Michael
    Borthakur, Gautam
    Kadia, Tapan
    Cortes, Jorge
    Kantarjian, Hagop M.
    Khoury, Joseph D.
    BLOOD, 2016, 127 (15) : 1863 - 1869
  • [4] Outcomes of adult patients with early T-cell precursor (ETP) acute lymphoblastic leukemia/lymphoma (ALL) and non-ETP T-ALL
    Onishi, Yasushi
    Furukawa, Eijiro
    Kamata, Mayumi
    Fukatsu, Masahiko
    Kameoka, Yoshihiro
    Hatta, Shunsuke
    Hamada, Hiroyuki
    Oyake, Tatsuo
    Kai, Tatsuyuki
    Sukegawa, Masumi
    Nakajima, Shinji
    Yanagiya, Ryo
    Yamaguchi, Kohei
    Takahashi, Taro
    Harazaki, Yoriko
    Izumi, Toru
    Murai, Kazunori
    Ito, Shigeki
    Ikezoe, Takayuki
    Ishizawa, Kenichi
    Takahashi, Naoto
    Harigae, Hideo
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2023, 117 (05) : 738 - 747
  • [5] A Comparative Analysis of Early T-Cell Precursor Lymphoblastic Leukemia/Lymphoma (ETP-ALL/LBL) and Non-ETP-ALL/LBL in a Tertiary Cancer Care Center Based in Western India
    Saha, Anurag
    Brahmbhatt, Beena
    Rai, Varnika
    Kakoty, Sneha
    Sawhney, Jyoti
    INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2023, 39 (04) : 699 - 704
  • [6] The Proteomics of T-Cell and Early T-Cell Precursor (ETP) Acute Lymphocytic Leukemia: Prognostic Patterns in Adult and Pediatric-ETP ALL
    Hoff, Fieke W.
    Sriraja, Lourdes
    Qiu, Yihua
    Jenkins, Gaye N.
    Teachey, David T.
    Wood, Brent
    Devidas, Meenakshi
    Shockley, Shaina
    Loh, Mignon L.
    Petsalaki, Evangelia
    Kornblau, Steven M.
    Horton, Terzah M.
    CANCERS, 2024, 16 (24)
  • [7] Comparison of Early T-Cell Precursor and Non-ETP Subtypes Among 122 Chinese Adults With Acute Lymphoblastic Leukemia
    Zhang, Yi
    Qian, Jie-Jing
    Zhou, Yi-Le
    Huang, Xin
    Li, Jian-Hu
    Li, Xue-Ying
    Li, Chen-Ying
    Wang, Huan-Ping
    Lou, Yin-Jun
    Meng, Hai-Tao
    Yu, Wen-Juan
    Tong, Hong-Yan
    Jin, Jie
    Zhu, Hong-Hu
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [8] Immunophenotypic analysis of T-acute lymphoblastic leukemia. A CD5-based ETP-ALL perspective of non-ETP T-ALL
    Chopra, Anita
    Bakhshi, Sameer
    Pramanik, Suman Kumar
    Pandey, Ravindra Mohan
    Singh, Saroj
    Gajendra, Smeeta
    Gogia, Ajay
    Chandramohan, Jagan
    Sharma, Atul
    Kumar, Lalit
    Seth, Rachna
    Rai, Sandeep
    Kumar, Rajive
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 92 (03) : 211 - 218
  • [9] Early T-cell precursor acute lymphoblastic leukaemia
    Haydu, J. Erika
    Ferrando, Adolfo A.
    CURRENT OPINION IN HEMATOLOGY, 2013, 20 (04) : 369 - 373
  • [10] Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
    Castaneda Puglianini, Omar
    Papadantonakis, Nikolaos
    THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 11
12345